Bratisl Lek Listy. 2022;123(8):573-578. doi: 10.4149/BLL_2022_092.
Adipose tissue is involved in the synthesis of hormones that have an impact on food intake regulation, control of insulin sensitivity or regulation of inflammatory processes. The aim of this study was to determine the importance of adipocytokines and interleukins levels for the development of post-transplant diabetes mellitus (PTDM) after kidney transplantation (KT).
In the prospective analysis, the studied sample (n = 104) was divided into the control group, prediabetes group and PTDM group. Prior to transplantation, and subsequently, at 3, 6 and 12 months after KT, we recorded the basic characteristics of the donor and recipient, including parameters reflecting graft function, metabolic and anthropometric parameters. At the same time, we monitored the levels of adiponectin, leptin and interleukins during the monitored period.
Using multivariate logistic regression, we identified hyperleptinemia 12 months after KT as an independent risk factor for PTDM development 1 year after KT [OR 1.0320; 95% Cl 0.9785-1.0884 (p=0.0038)]. At the same time, we confirmed that age at the time of KT is also an independent risk factor for PTDM [OR 1.0903; 95% Cl 1.0149-1.1714 (p=0.0180)].
We confirmed that elevated leptin level 12 months after KT is associated with the development of PTDM (Tab. 3, Fig. 4, Ref. 22). Text in PDF www.elis.sk Keywords: adipocytokines, interleukins, post-transplant diabetes mellitus, kidney transplantation, leptin.
脂肪组织参与合成激素，这些激素会影响食物摄入的调节、胰岛素敏感性的控制或炎症过程的调节。本研究的目的是确定脂肪细胞因子和白细胞介素水平对肾移植（KT）后发生移植后糖尿病（PTDM）的重要性。
在前瞻性分析中，研究样本（n=104）分为对照组、糖尿病前期组和 PTDM 组。在移植前，以及随后在 KT 后 3、6 和 12 个月，我们记录了供体和受体的基本特征，包括反映移植物功能、代谢和人体测量参数的参数。同时，我们在监测期间监测了脂联素、瘦素和白细胞介素的水平。
使用多变量逻辑回归，我们确定 KT 后 12 个月的高瘦素血症是 KT 后 1 年发生 PTDM 的独立危险因素[OR 1.0320；95% Cl 0.9785-1.0884（p=0.0038）]。同时，我们证实 KT 时的年龄也是 PTDM 的独立危险因素[OR 1.0903；95% Cl 1.0149-1.1714（p=0.0180）]。
我们证实 KT 后 12 个月瘦素水平升高与 PTDM 的发生有关（表 3、图 4、参考文献 22）。
