Department of Experimental and Clinical Medicine University of Florence, Largo Brambilla 3, 50134, Florence, Italy.
Department of Experimental and Clinical Medicine University of Florence, Largo Brambilla 3, 50134, Florence, Italy.
Respir Med. 2022 Aug-Sep;200:106929. doi: 10.1016/j.rmed.2022.106929. Epub 2022 Jul 14.
In patients with chronic cough and age-matched control subjects, we attempted to evoke coughing and/or an urge to cough (UTC) by finger pressure along the sternocleidomastoid and sternum, on the lower cervical or first dorsal vertebrae, the jugular notch as well as with maximum neck extension and flexion These mechanical actions were ineffective in controls but reproducibly evoked coughing or UTC in about 50% of chronic coughers; sternal and spinal responses were abolished temporarily by local cooling. The results may disclose a novel paradigm of cough sensitisation possibly involving central convergence of somatic and visceral neural stimuli.
在慢性咳嗽患者和年龄匹配的对照者中,我们试图通过沿着胸锁乳突肌和胸骨、颈下部或第一胸椎、颈静脉切迹施加手指压力,以及最大程度地伸展和弯曲颈部来诱发咳嗽和/或咳嗽冲动(UTC)。这些机械动作在对照组中无效,但在约 50%的慢性咳嗽患者中可重复性地诱发咳嗽或 UTC;胸骨和脊柱的反应被局部冷却暂时消除。这些结果可能揭示了一种新的咳嗽敏化范式,可能涉及躯体和内脏神经刺激的中枢会聚。