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两种新型 3D 超分子配合物:光催化性能及胃癌治疗活性。

Two New 3D Supramolecular Complexes: Photocatalytic Properties and Treatment Activity for Gastric Cancer.

机构信息

Department of Surgery, Tinglin Hospital of Jinshan District, Shanghai, 201505, China.

出版信息

J Biomed Nanotechnol. 2022 Apr 1;18(4):1028-1034. doi: 10.1166/jbn.2022.3325.

Abstract

Two new coordination polymers, [Cu₂(5-MeO-Hip)₄(py)₄] () and [Co(5-EtO-ip)(4,4'-bipy)]·n(MeOH) () (5-MeO-H₂ip is 5-methoxyisophthalic acid, 5-EtO-H₂ip is 5-ethoxyisophthalic acid, py is pyridine, and 4,4'-bipy is 4,4'-bipyridine), were created via solvothermal self-assembly. The thermal steadiness and photocatalytic functions of and were detected, and their application values in gastric cancer and the related mechanism were discussed. CCK-8 assay was used to determine the inhibitory activity toward gastric cancer cells' viability, and real-time RT-PCR was employed to examine the gastric cancer cells' Notch signaling pathway activity.

摘要

两个新的配位聚合物,[Cu₂(5-MeO-Hip)₄(py)₄] () 和 [Co(5-EtO-ip)(4,4'-bipy)]·n(MeOH) ()(5-MeO-H₂ip 是 5-甲氧基异酞酸,5-EtO-H₂ip 是 5-乙氧基异酞酸,py 是吡啶,4,4'-bipy 是 4,4'-联吡啶),通过溶剂热自组装合成。对 和 的热稳定性和光催化性能进行了检测,并探讨了它们在胃癌中的应用价值及其相关机制。CCK-8 法测定对胃癌细胞活力的抑制活性,实时 RT-PCR 检测胃癌细胞 Notch 信号通路活性。

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