Ryu Soo Ho, Kim Nayeon, Kim Chaeyeong, Bae Jong-Sup
College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, Republic of Korea.
Int J Environ Health Res. 2023 Dec;33(12):1479-1489. doi: 10.1080/09603123.2022.2102156. Epub 2022 Jul 19.
Fine particulate matter (PM) is an air pollutant that causes severe lung injury. We investigated the effects of Jujuboside B (JB), a component of Zizyphi Spinosi Semen, on lung toxicity caused by PM, and we identified the mechanism of its protective effect. Lung injury in an animal model was induced by intratracheal administration of a PM suspension. After 2 days of PM pretreatment, mice were administered JB via the tail vein three times over a 2-day period. JB significantly reduced the histological lung damage as well as the lung wet/dry weight ratio. JB also considerably reduced PM-induced autophagy dysfunction, apoptosis, inflammatory cytokine levels, and the number of PM-induced lymphocytes in the bronchial alveolar fluid. We conclude that by regulating TLR2, 4-MyD88, and mTOR-autophagy pathways, JB exerts a protective effect on lung injury. Thus, JB can be used as a potential therapeutic agent for PM-induced lung damage.
细颗粒物（PM）是一种可导致严重肺损伤的空气污染物。我们研究了酸枣仁的成分酸枣仁皂苷B（JB）对PM所致肺毒性的影响，并确定了其保护作用的机制。通过气管内给予PM悬浮液诱导动物模型中的肺损伤。在PM预处理2天后，小鼠在2天内通过尾静脉接受3次JB给药。JB显著减轻了组织学上的肺损伤以及肺湿/干重比。JB还大大减少了PM诱导的自噬功能障碍、细胞凋亡、炎性细胞因子水平以及支气管肺泡液中PM诱导的淋巴细胞数量。我们得出结论，通过调节TLR2、4-MyD88和mTOR-自噬途径，JB对肺损伤发挥保护作用。因此，JB可作为PM所致肺损伤的潜在治疗药物。
