Kumura D, Miller J H, Sinatra F R
J Nucl Med. 1987 Jun;28(6):966-72.
Septo-optic dysplasia (SOD), an unusual clinical syndrome associated with intrahepatic cholestasis, is a cause of false-positive hepatobiliary scintigraphy in patients with neonatal jaundice. Use of the criterion of absence of [99mTc]IDA activity in the gastrointestinal tract by 24 hr, as well as application of the more recently used criterion of normal hepatic extraction, failed to differentiate patients with biliary atresia from those with SOD. Septo-optic dysplasia has clinical and scintigraphic features unique from other causes of conjugated hyperbilirubinemia. Identification of the patients with SOD, in a group of 44 infants being evaluated for neonatal jaundice, improved the overall specificity of hepatobiliary scintigraphy in neonatal jaundice from 65% to 79% and accuracy in identification of patients with biliary atresia from 82% to 90%. Recognition of SOD is important to prevent unnecessary surgical exploration of these patients.
视隔发育不良（SOD）是一种与肝内胆汁淤积相关的罕见临床综合征，是新生儿黄疸患者肝胆闪烁显像假阳性的一个原因。采用24小时胃肠道内无[99mTc]IDA活性这一标准，以及应用最近使用的肝脏摄取正常这一标准，均无法区分胆道闭锁患者和SOD患者。视隔发育不良具有与其他结合胆红素血症病因不同的临床和闪烁显像特征。在一组接受新生儿黄疸评估的44例婴儿中识别出SOD患者，使新生儿黄疸肝胆闪烁显像的总体特异性从65%提高到79%，识别胆道闭锁患者的准确性从82%提高到90%。认识到SOD对于避免对这些患者进行不必要的手术探查很重要。
