Unit of Occupational Medicine and Environmental Research, Department of Public Health, Faculty of Medicine, University of Lubumbashi, Lubumbashi, Democratic Republic of the Congo.
Occupational Health and Safety Department, Kibali Gold Mine, Barrick Gold Corporation, Doko, Haut-Uélé Province, Democratic Republic of the Congo.
Pan Afr Med J. 2022 Apr 11;41:291. doi: 10.11604/pamj.2022.41.291.33047. eCollection 2022.
Acute acalculous cholecystitis is an acute inflammation of the gallbladder in the absence of stones, usually occurring in elderly and critically ill patients with underlying conditions. A 29-year-old man presented to the hospital complaining of abdominal pain in the right hypochondrium with permanent fever three days after Janssen COVID-19 vaccine inoculation. Abdominal ultrasound revealed a thickened gallbladder wall without evidence of gallstone consistent of an acute acalculous cholecystitis. Blood analyses revealed thrombocytopenia, eosinophilia and liver dysfunction. The Polymerase Chain Reaction (PCR) COVID-19 test was negative. As treatment, the patient benefited of pain management, antibiotic and fluid. In the evolution, there was a regression of clinical signs with persistence of liver dysfunction. The patient was discharged ten days after hospitalization. The Janssen COVID-19 vaccine is likely to induce acute acalculous cholecystitis as adverse event following vaccination.
急性非结石性胆囊炎是一种胆囊的急性炎症，无结石，通常发生在有基础疾病的老年和重症患者中。一名 29 岁男性因接种强生 COVID-19 疫苗后三天出现右上腹疼痛和持续发热，到医院就诊。腹部超声显示胆囊壁增厚，无胆结石证据，符合急性非结石性胆囊炎。血液分析显示血小板减少、嗜酸性粒细胞增多和肝功能异常。聚合酶链反应（PCR）COVID-19 检测结果为阴性。治疗上，患者接受了止痛、抗生素和补液治疗。在疾病进展过程中，临床症状有所缓解，但肝功能仍未恢复正常。患者在住院十天后出院。强生 COVID-19 疫苗可能会引发接种后不良反应导致急性非结石性胆囊炎。
