Fung Eva Lai-Wah, Mo Chung-Yin, Fung Sharon Tsui-Hang, Chan Anne Yin-Yan, Lau Ka-Yee, Chan Emily Kit-Ying, Chan David Yuen-Chung, Zhu Xian-Lun, Chan Danny Tat-Ming, Poon Wai-Sang
Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong.
Department of Paediatrics, Kwong Wah Hospital, Hong Kong.
Surg Neurol Int. 2022 Jul 1;13:285. doi: 10.25259/SNI_166_2022. eCollection 2022.
is an emerging disorder characterized with hypotonia, developmental delay, epilepsy, and movement disorder, which can be potentially life threatening during acute exacerbation. In the USA, deep brain stimulation (DBS) has been licensed for treating children with chronic, treatment-resistant primary dystonia, who are 7 years old or older.
A 4-year-old girl diagnosed to have related dyskinesia and severe global developmental delay. She had severe dyskinesia precipitated by intercurrent infection, requiring prolonged intensive care for heavy sedation and related complications. Her dyskinesia improved dramatically after DBS implantation. Technical difficulties and precautions of DBS in preschool children were discussed.
DBS should be considered early in the treatment of drug-resistant movement disorders in young children with , especially after dyskinetic crisis, as they tend to recur. Presurgical counseling to parents and close monitoring of complications is also important in the process.
是一种新兴的疾病，其特征为肌张力减退、发育迟缓、癫痫和运动障碍，在急性加重期可能危及生命。在美国，深部脑刺激（DBS）已被批准用于治疗7岁及以上患有慢性、难治性原发性肌张力障碍的儿童。
一名4岁女孩被诊断患有相关运动障碍和严重的全面发育迟缓。她因并发感染而出现严重运动障碍，需要长时间重症监护以进行深度镇静及处理相关并发症。在植入DBS后，她的运动障碍得到显著改善。讨论了DBS在学龄前儿童中的技术难点及注意事项。
对于患有运动障碍的幼儿，尤其是在运动障碍危象后，由于症状易复发，应在治疗耐药性运动障碍时尽早考虑DBS。在此过程中，对家长进行术前咨询以及密切监测并发症也很重要。
