Ladenheim Alexander, Mitra Ananya Datta, Lechpammer Mirna, Dwyre Denis M
Department of Pathology and Laboratory Medicine, University of California Davis Health, Sacramento, California.
Department of Pathology, Foundation Medicine, Cambridge, Massachusetts, United States.
Surg Neurol Int. 2022 Jun 23;13:267. doi: 10.25259/SNI_828_2021. eCollection 2022.
Extramedullary hematopoiesis (EMH) and plasmacytomas occurring within the cranium are rare entities.
We review two cases in which patients presented with subdural hematoma and underwent evacuation. On routine histopathologic examination of their membranes, both patients were subsequently found to have focal EMH, as well as a clonal plasma cell proliferation in one case.
EMH is rare and usually found in individuals with profound and chronic anemia. However, this entity may be more common in chronic subdural hematomas. Solitary extraosseous plasmacytoma is exceedingly rare in the cranium, and its presence in chronic subdural hematoma membranes is of uncertain significance. The cytokine milieu that promotes organization of chronic subdural hematomas may play a role in the establishment of both of entities in this location.
髓外造血(EMH)和发生于颅骨内的浆细胞瘤是罕见的病症。
我们回顾了两例患者,他们均表现为硬膜下血肿并接受了血肿清除术。在对其脑膜进行常规组织病理学检查时,两名患者随后均被发现有局灶性髓外造血,其中一例还存在克隆性浆细胞增殖。
髓外造血很罕见,通常见于患有严重慢性贫血的个体。然而,这一病症在慢性硬膜下血肿中可能更为常见。孤立性骨外浆细胞瘤在颅骨中极为罕见,其在慢性硬膜下血肿脑膜中的存在意义尚不确定。促进慢性硬膜下血肿机化的细胞因子环境可能在该部位这两种病症的发生中起作用。