Lairon D, Lacombe C, Borel P, Corraze G, Nibbelink M, Chautan M, Chanussot F, Lafont H
J Nutr. 1987 May;117(5):838-45. doi: 10.1093/jn/117.5.838.
Adult male rats were fed for 7 wk either a low fat diet (3% fat) or a high fat-cholesterol diet (20% fat, 0.5% cholesterol) containing 7% wheat germ or not. Body weights and food intakes were unchanged by adding wheat germ to the control low fat or high fat diets. Adding wheat germ to the high fat-cholesterol diet significantly increased high density lipoprotein (HDL) cholesterol and the HDL-serum cholesterol ratio and lowered the very low density lipoprotein (VLDL) triglycerides. Thus the lipoprotein pattern was comparable to that obtained with the low fat diet, but the VLDL lipid composition remained altered. At the same time, triglyceride and cholesterol accumulation in the liver and the triglyceride content in skin were significantly decreased. When wheat germ was added to the low fat diet, cholesterol and triglycerides were not significantly modified. No adaptative change in lipase and colipase contents was observed in the pancreas of rats fed the wheat germ-supplemented diets, whereas the high fat diet increased these values. The results show a beneficial effect of wheat germ added to a high fat-cholesterol diet on the lipid status of rats; the implicated mechanisms are yet to be elucidated.
成年雄性大鼠分别喂食低脂饮食（3%脂肪）或高脂 - 胆固醇饮食（20%脂肪，0.5%胆固醇）7周，其中部分高脂 - 胆固醇饮食组含7%小麦胚芽，部分不含。在对照低脂或高脂饮食中添加小麦胚芽对体重和食物摄入量无影响。在高脂 - 胆固醇饮食中添加小麦胚芽可显著增加高密度脂蛋白（HDL）胆固醇及HDL - 血清胆固醇比值，并降低极低密度脂蛋白（VLDL）甘油三酯。因此，脂蛋白模式与低脂饮食时相当，但VLDL脂质组成仍有改变。同时，肝脏中甘油三酯和胆固醇的积累以及皮肤中的甘油三酯含量显著降低。当在低脂饮食中添加小麦胚芽时，胆固醇和甘油三酯无显著变化。在喂食添加小麦胚芽饮食的大鼠胰腺中，未观察到脂肪酶和辅脂肪酶含量的适应性变化，而高脂饮食会增加这些值。结果表明，在高脂 - 胆固醇饮食中添加小麦胚芽对大鼠脂质状态有有益影响；其中涉及的机制尚待阐明。
