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新冠病毒疫苗接种与面瘫的潜在关联:伴有神经影像学发现的三例病例。

Potential Association Between COVID-19 Vaccination and Facial Palsy: Three Cases With Neuroimaging Findings.

机构信息

Department of Radiology, Istanbul University-Cerrahpasa Cerrahpasa Medical Faculty, Fatih, Turkey.

Department of Neurology, University of Health Sciences Istanbul Prof. Dr Cemil Tascioglu City Hospital, Okmeydani, Turkey.

出版信息

Ear Nose Throat J. 2024 Jun;103(1_suppl):110S-114S. doi: 10.1177/01455613221113818. Epub 2022 Jul 19.

Abstract

Acute onset Facial palsy was reported in four vaccinated participants in the BNT162b2 (Pfizer-BioNTech) vaccine clinical trials published on December 10, 2020. So far, few cases of Facial palsy among the mRNA vaccine groups have been previously documented in the literature. Facial palsy is cited as medically attended adverse event following immunization on April 12, 2021, after the first dose of the approved Pfizer-BioNTech COVID-19 vaccines for preventive immunization for SARS-CoV-2 is administrated to the population in Turkey. This study is aimed to describe clinical and magnetic resonance imaging features of three patients, who developed acute onset peripheral facial paralysis after administration of the BNT162b2 vaccine, without any previous medical condition. The first patient presented with right sided facial palsy within the same day following the vaccine was administrated, while the second patient presented with left sided facial palsy 2 months after vaccination. The third patient, on the other hand, presented with right sided facial palsy and abducens nerve (CN VI) paralysis two days after vaccine was administrated.

摘要

2020 年 12 月 10 日发表的 BNT162b2(辉瑞-生物科技)疫苗临床试验报告称,有 4 名接种者出现急性面瘫。到目前为止,在文献中很少有先前记录的 mRNA 疫苗组中的面瘫病例。面瘫被列为接种后出现的需要医疗干预的不良事件,2021 年 4 月 12 日,在土耳其批准的辉瑞-生物科技公司用于预防 SARS-CoV-2 的 COVID-19 疫苗进行人群预防性免疫接种的第一针后出现。本研究旨在描述 3 名无任何既往病史的患者在接种 BNT162b2 疫苗后发生急性周围性面瘫的临床和磁共振成像特征。第一例患者在接种当天出现右侧面瘫,第二例患者在接种后 2 个月出现左侧面瘫。第三例患者在接种后两天出现右侧面瘫和展神经(CN VI)麻痹。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a39/9301354/cb7273359b4d/10.1177_01455613221113818-fig1.jpg

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