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病毒定量分析的安全距离及空气中呼吸道含病原体飞沫轨迹的模拟

Safe Distance of Virus Quantitative Analysis and Simulation of the Trajectory of Pathogen-Containing Droplets in the Air Respiratory Airways.

作者信息

Miao Hanwen Alvin

机构信息

Princeton International School of Mathematics and Science, Princeton, New Jersey, USA.

出版信息

Appl Bionics Biomech. 2022 Jul 15;2022:4218342. doi: 10.1155/2022/4218342. eCollection 2022.

Abstract

Droplets of mucosalivary ejecta emitted by sneezing or coughing are a major carrier of numerous types of bacterial and viral diseases. This study develops a numerical model to estimate the spread distance for inhalable droplets (1-50 m) in the air, the inhalability of the particles, and the trajectory as well as velocity of these pathogen-containing droplets in human respiratory airways. Moreover, particularly for droplets with diameters of 1 m, 5 m, 10 m, and 50 m, specific comparisons between their inhalability and transmission velocities are made. Data extracted from previous experiments proceeded by other researchers discussing the visualization of sneeze ejecta and deposition features of inhaled drops were used to obtain parameters to fit the model prediction of this work. Currently, research on similar topics was mostly based on either experiments or theoretical calculations only on one specific clan of pathogen, while the novel contribution of this paper is the combination and comparison of these two distinct methodologies that can be applied to solve a general practical problem aiming to all types of viruses by considering the pathogen-containing droplets as a whole entity.

摘要

打喷嚏或咳嗽喷出的粘膜唾液飞沫是多种细菌和病毒疾病的主要传播载体。本研究建立了一个数值模型,用于估计空气中可吸入飞沫(1-50微米)的传播距离、颗粒的可吸入性,以及这些含病原体飞沫在人体呼吸道中的轨迹和速度。此外,特别针对直径为1微米、5微米、10微米和50微米的飞沫,对它们的可吸入性和传播速度进行了具体比较。从其他研究人员先前进行的讨论喷嚏喷出物可视化和吸入飞沫沉积特征的实验中提取的数据,用于获取参数以拟合本研究的模型预测。目前,关于类似主题的研究大多仅基于实验或仅针对某一特定病原体种类的理论计算,而本文的新颖贡献在于将这两种不同方法进行结合和比较,通过将含病原体飞沫视为一个整体实体,可应用于解决针对所有类型病毒的一般实际问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c744/9287783/2acb8ad7470b/ABB2022-4218342.001.jpg

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