Soufi Aya, Nokta Abeer Abo, Alshehabi Zuheir, Alhussein Firas
Faculty of Medicine, Tishreen University, Latakia, Syria.
Department of Pathology, Cancer Research Centre, Faculty of Medicine, Tishreen University, Latakia, Syria.
Ann Med Surg (Lond). 2022 Jul 9;80:104128. doi: 10.1016/j.amsu.2022.104128. eCollection 2022 Aug.
Sarcoidosis is a chronic systematic inflammatory disorder of unknown etiology. Marginal zone lymphoma is a well-varied family of lymphomas that makes up to 10% of the overall non-Hodgkin's lymphomas. The relationship between sarcoidosis and multiple diseases was mentioned repeatedly in the literature, whereas the relationship between sarcoidosis and marginal zone lymphoma was found rare. This case presents a 56-years-old man who was diagnosed with sarcoidosis after treatment of marginal zone lymphoma.
A 56-year-old male presented to Tishreen University Hospital (TUH) Gastrointestinal department with abdominal pain, vomiting, loss of apetite, fever, and unintentional weight loss. Computerized tomography scan of the chest and abdomen, in addition to the excisional biopsy of the cervical nodes, were both highly suggestive of marginal zone lymphoma. After completing a course of chemotherapy, the patient returned with generalized abdominal discomfort, anorexia, and fatigue. Computerized tomography illustrated enlarged mediastinal lymph nodes in the chest and the abdomen. Microscopic examination of an abdominal lymph node revealed granulomatous lymphadenitis with sarcoidosis. Thereafter, the patient was managed with nonsteroidal anti-inflammatory drugs and corticosteroids.
We describe the occurrence of sarcoidosis after the treatment of marginal zone lymphoma. In most cases, sarcoidosis precedes lymphomas. This case emphasizes the evidence on the possible relationship between lymphomas and sarcoidosis, and attention should be sought towards any new manifestations throughout the follow-up of patients diagnosed with lymphomas toward sarcoidosis as part of our differential diagnosis.
结节病是一种病因不明的慢性系统性炎症性疾病。边缘区淋巴瘤是一组种类繁多的淋巴瘤，占非霍奇金淋巴瘤总数的10%。结节病与多种疾病之间的关系在文献中被反复提及，而结节病与边缘区淋巴瘤之间的关系则较为罕见。本病例报告了一名56岁男性，在接受边缘区淋巴瘤治疗后被诊断为结节病。
一名56岁男性因腹痛、呕吐、食欲不振、发热和体重意外减轻就诊于提什林大学医院（TUH）胃肠科。胸部和腹部的计算机断层扫描以及颈部淋巴结切除活检均高度提示边缘区淋巴瘤。在完成一个化疗疗程后，患者因全身腹部不适、厌食和疲劳复诊。计算机断层扫描显示胸部和腹部纵隔淋巴结肿大。对一个腹部淋巴结的显微镜检查显示为结节病性肉芽肿性淋巴结炎。此后，患者接受了非甾体抗炎药和皮质类固醇治疗。
我们描述了边缘区淋巴瘤治疗后发生结节病的情况。在大多数情况下，结节病先于淋巴瘤出现。本病例强调了淋巴瘤与结节病之间可能存在关系的证据，在对诊断为淋巴瘤的患者进行随访时，应关注任何新出现的表现，将结节病作为鉴别诊断的一部分。
