Department of Microbiology and Biochemistry, Faculty of Pharmacy, Al-Sham Private University (ASPU), Latakia, Syria.
Eur Rev Med Pharmacol Sci. 2022 Jul;26(13):4654-4658. doi: 10.26355/eurrev_202207_29187.
Colorectal cancer represents the third most common malignancy and the second leading cause of cancer deaths worldwide. Many factors contribute to the risk of developing colorectal carcinoma including diet, lifestyle, age, and genetic abnormalities. Recent findings have shown a considerable increase in the incidence rate of CRC in developing countries. However, there is little information regarding its incidence in the Middle East countries, including Syria. With our manuscript we aimed at presenting the first large epidemiological study regarding colorectal carcinoma incidence in Syria.
We conducted a retrospective study on colorectal carcinoma cases at our institution from 2014 to 2018. The data include the cases that were diagnosed and recorded based on multiple parameters including gender, age, year of diagnosis, city of origin, and profession.
The number of colorectal cancer cases was 1,117 out of 13,589 cases of all malignant tumors recorded from 2014 to 2018, with an annual average incidence of 8.2%. There was a statistically significant difference in CRC cases according to age and gender. We also found a statistically significant difference according to physical activity and occupation.
These results demonstrate that risk factors related to colorectal cancer incidence in Syria mainly include male sex, age over 50 years old, and occupation with no physical activity.
结直肠癌是全球第三大常见恶性肿瘤，也是癌症死亡的第二大主要原因。许多因素会增加罹患结直肠癌的风险，包括饮食、生活方式、年龄和遗传异常。最近的研究结果表明，发展中国家 CRC 的发病率有相当大的增加。然而，关于中东国家（包括叙利亚）CRC 的发病率的信息却很少。通过我们的研究，旨在介绍叙利亚结直肠癌发病率的第一项大型流行病学研究。
我们对 2014 年至 2018 年在我们机构诊断的结直肠癌病例进行了回顾性研究。这些数据包括基于多种参数（包括性别、年龄、诊断年份、原籍城市和职业）诊断和记录的病例。
2014 年至 2018 年期间，共记录了 13589 例恶性肿瘤，其中结直肠癌病例为 1117 例，年平均发病率为 8.2%。CRC 病例在年龄和性别方面存在统计学显著差异。我们还发现根据体力活动和职业存在统计学显著差异。
这些结果表明，与叙利亚结直肠癌发病率相关的危险因素主要包括男性、50 岁以上和无体力活动的职业。
