Department of Chemistry, Faculty of Science, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic.
RECETOX, Faculty of Science, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic.
Chem Commun (Camb). 2022 Aug 9;58(64):8958-8961. doi: 10.1039/d2cc02648a.
Here we report on carbon monoxide-photoreleasable compounds (photoCORMs) that combine heptamethine cyanine and flavonol chromophores and are activated upon irradiation with near-infrared light. Excellent CO-release yields and uncaging cross sections in aqueous solutions, enhanced water solubilities thanks to polar substituents or a host-guest approach using cucurbit[7]uril are demonstrated. The hybrids display outstanding biocompatibility and diverse, structure-dependent cell penetrability and internalization.
在这里，我们报告了一氧化碳光释放化合物（photoCORMs），它们结合了七甲川菁和黄酮醇发色团，并在近红外光照射下被激活。在水溶液中，它们表现出优异的 CO 释放产率和光解截面，由于极性取代基或使用葫芦[7]脲的主体-客体方法，其水溶性得到增强。这些杂化物表现出出色的生物相容性和多样的、结构依赖性的细胞穿透性和内化能力。
