使用氧化氘一锅法连续进行氢同位素交换/还原氘代反应制备α，β-氘代醇。
One-Pot Sequential Hydrogen Isotope Exchange/Reductive Deuteration for the Preparation of α,β-Deuterated Alcohols using Deuterium Oxide.
机构信息
Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.
Department of Chemistry and Innovation Center of Pesticide Research, China Agricultural University, Beijing 100193, China.
出版信息
Org Lett. 2022 Jul 29;24(29):5319-5323. doi: 10.1021/acs.orglett.2c01940. Epub 2022 Jul 20.
An efficient one-pot sequential hydrogen isotope exchange (HIE)/reductive deuteration approach was developed for the preparation of α,β-deuterated alcohols using ketones as the precursors. The HIE step can also be used for the synthesis of α-deuterated ketones. This method has been applied in the synthesis of four deuterated drug and MS internal standards.
开发了一种高效的一锅顺序氢同位素交换（HIE）/还原氘代方法，用于使用酮作为前体制备α，β-氘代醇。HIE 步骤也可用于合成α-氘代酮。该方法已应用于四种氘代药物和 MS 内标物的合成。
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