Carbon dots with intrinsic theranostic properties for photodynamic therapy of oral squamous cell carcinoma.

Carbon dots (CDs) are one of the carbon-based materials with remarkable optical properties, good water dispersibility and high biocompatibility. However, few studies have emphasized the intrinsic photodynamic and anticancer properties of CDs. Herein, we used CDs as photosensitizers to explore their photodynamic therapy (PDT) effect on oral squamous cell carcinoma (OSCC) cells. The obtained CDs had an effective cellular internalization capacity and possessed good biocompatibility in both CAL-27 and UM1 cells. After irradiation, the CDs showed obvious photodynamic effects on the test cells, which were confirmed by apoptosis analysis. In addition, the CDs exhibited excellent intracellular ROS generation under irradiation, and the subsequent induced cell death may be related to a lysosome-associated pathway.