González L Roberto, Barra M Sebastián, Riquelme U Alejandra, Reyes M Rodrigo, Spencer L M Loreto, Alarcón O Felipe, Seguel S Enrique, Stockins L Aleck, Jadue T Andrés, Saldivia Z Diego, Schaub C AndréS, Alarcón C Emilio
Centro Cardiovascular, Hospital Clínico Regional de Concepción: "Dr. Guillermo Grant Benavente", Concepción, Chile.
Facultad de Medicina, Universidad de Concepción, Concepción, Chile.
Rev Med Chil. 2022 Jan;150(1):7-16. doi: 10.4067/S0034-98872022000100007.
Lung cancer is the world's leading cause of cancer death.
To describe the clinical, staging and survival characteristics of lung cancer in a public Chilean regional hospital.
Analysis of a prospective database of a thoracic surgery service, retrieving histologically confirmed lung cancer cases from January 2010 to December 2019 and reviewing their medical records. Cases were re-staged by the TNM-8 system and variables were compared between periods 2010-2014 and 2015-2019.
We retrieved 551 lung cancer cases, 333 (60 %) men, with a mean age of 65 years. Distant metastases were found in 72% of cases (excluding lymphatic metastases). Of the non-small cell lung cancers (NSCLC), 50 (10%) cases were in stage I, 18 (4%) in stage II, 81 (16%) in stage III and 347 (70%) in stage IV. Global five-year survival was 18%, 20% for NSCLC, 71% for excised NSCLC, 8% for non-excised NSCLC, 88% for stage I and 92% for subgroup IA. Resective surgery was performed in 81 (14%) cases. When comparing 2010-2014 and 2015-2019 periods, the frequency of resective surgery increased from 7% to 20%.
The diagnosis of lung cancer was frequently made in advanced stages. There was a significant increase in early diagnosis and frequency of surgeries with curative intent in the second observation period.
肺癌是全球癌症死亡的主要原因。
描述智利一家公立地区医院肺癌的临床、分期和生存特征。
分析胸外科前瞻性数据库，检索2010年1月至2019年12月经组织学确诊的肺癌病例并查阅其病历。病例按TNM-8系统重新分期，并比较2010 - 2014年和2015 - 2019年期间的变量。
我们检索到551例肺癌病例，其中男性333例（60%），平均年龄65岁。72%的病例发现有远处转移（不包括淋巴转移）。在非小细胞肺癌（NSCLC）中，50例（10%）为I期，18例（4%）为II期，81例（16%）为III期，347例（70%）为IV期。总体五年生存率为18%，NSCLC为20%，切除的NSCLC为71%，未切除的NSCLC为8%，I期为88%，IA亚组为92%。81例（14%）病例进行了根治性手术。比较2010 - 2014年和2015 - 2019年期间，根治性手术的频率从7%增加到20%。
肺癌诊断多在晚期。在第二个观察期，早期诊断和根治性手术频率显著增加。
