Department of Cardiology, Herlev-Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark,
Department of Cardiology, Herlev-Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Neonatology. 2022;119(5):629-637. doi: 10.1159/000524439. Epub 2022 Jul 20.
Previous studies have suggested an increased prevalence of congenital heart disease among children born to women aged ≥35 years. In recent decades, the mother's age at childbirth has increased dramatically in industrialized countries. It has not been investigated if increasing maternal age affects the neonatal cardiac electrical system.
The Copenhagen Baby Heart Study is a prospective general population study that performed cardiac evaluation in newborns. Electrocardiograms were analyzed with a computerized algorithm.
We included 16,518 newborns with normal echocardiograms (median age 11 days; range 0-30 days; 52% boys). Median maternal age at delivery was 31 years; 790 newborns were born to mothers aged between 16 and 24 years, 11,403 between 25 and 34 years, 4,279 between 35 and 44 years, and 46 newborns had mothers aged between 45 and 54 years. The QRS axis and maximum R-wave amplitude in V1 (R-V1) differed across the four maternal age groups (both p < 0.01), with absolute differences of 3.5% (114 vs. 110°) and 12% (1,152 vs. 1,015 µV), respectively, between newborns with the youngest and oldest mothers. Associations between maternal age and the QRS axis and R-V1 remained significant after multifactorial adjustment. Heart rate, PR interval, QRS duration, uncorrected QT interval, QTcBazett, and maximum amplitudes of S-V1, R-V6, and S-V6 were not associated with maternal age (all p > 0.05).
We observed a significant association between maternal age and the neonatal QRS axis and R-V1. However, the absolute differences were relatively small and maternal age is unlikely to have a clinically significant effect on the neonatal cardiac electrical system.
先前的研究表明，母亲年龄≥35 岁所生子女先天性心脏病的患病率增加。近几十年来，工业化国家产妇的年龄显著增加。目前还没有研究表明，产妇年龄的增加是否会影响新生儿的心脏电系统。
哥本哈根婴儿心脏研究是一项前瞻性的一般人群研究，对新生儿进行心脏评估。心电图由计算机算法进行分析。
我们纳入了 16518 例超声心动图正常的新生儿（中位年龄 11 天；范围 0-30 天；52%为男性）。母亲的中位分娩年龄为 31 岁；790 例新生儿的母亲年龄在 16-24 岁之间，11403 例在 25-34 岁之间，4279 例在 35-44 岁之间，46 例新生儿的母亲年龄在 45-54 岁之间。四个母亲年龄组的 QRS 轴和 V1 导联的最大 R 波振幅（R-V1）不同（均 p<0.01），最年轻和最年长母亲的新生儿之间的绝对差值分别为 3.5%（114°比 110°）和 12%（1152µV 比 1015µV）。校正多因素后，母亲年龄与 QRS 轴和 R-V1 之间仍存在相关性。心率、PR 间期、QRS 持续时间、未校正 QT 间期、QTcBazett 和 S-V1、R-V6 和 S-V6 的最大振幅与母亲年龄无关（均 p>0.05）。
我们观察到母亲年龄与新生儿 QRS 轴和 R-V1 之间存在显著相关性。然而，绝对差异相对较小，母亲年龄不太可能对新生儿心脏电系统产生临床显著影响。
