Teuscher C, Smith S M, Tung K S
J Reprod Immunol. 1987 Mar;10(3):219-30. doi: 10.1016/0165-0378(87)90088-x.
Significant differences in susceptibility to the induction of experimental allergic orchitis (EAO) were found to exist among the various substrains of BALB/c mice. Substrains which were susceptible to disease induction include BALB/cKa, BALB/cByJ, BALB/cWtJ, BALB/cCmcCr, BALB/cCrgl, BALB/cHeA, BALB/cAnNCr, BALB/cPt, BALB/cWehiUnm, BALB/cOrnl and BALB/cArg whereas BALB/cJ and BALB/cSki BoyPt were resistant to EAO. Aspermatogenesis and autoimmune vasitis, two additional lesions characteristic of murine EAO, were found to correlate with susceptibility to autoimmune orchitis. Susceptibility and/or disease resistance did not segregate within any of the evolutionary branches of the BALB/c genealogic tree nor did it correlate with any of the previously described allelic differences distinguishing BALB/c substrains. Therefore, differential disease susceptibility may represent the manifestation of mutational and/or retroviral induced genotypic differences in the regulatory genes controlling testicular autoimmunity.
研究发现，BALB/c小鼠的不同亚系对实验性过敏性睾丸炎（EAO）诱导的易感性存在显著差异。易患疾病的亚系包括BALB/cKa、BALB/cByJ、BALB/cWtJ、BALB/cCmcCr、BALB/cCrgl、BALB/cHeA、BALB/cAnNCr、BALB/cPt、BALB/cWehiUnm、BALB/cOrnl和BALB/cArg，而BALB/cJ和BALB/cSki BoyPt对EAO具有抗性。精子发生障碍和自身免疫性输精管炎是小鼠EAO的另外两个特征性病变，它们与自身免疫性睾丸炎的易感性相关。在BALB/c系谱树的任何进化分支中，易感性和/或抗病性都没有分离，也与之前描述的区分BALB/c亚系的任何等位基因差异无关。因此，不同的疾病易感性可能代表了控制睾丸自身免疫的调节基因中突变和/或逆转录病毒诱导的基因型差异的表现。
