Steenstra R, Neblett H, Teuscher C
Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia 19104.
Autoimmunity. 1989;2(4):285-9. doi: 10.3109/08916938908997154.
BALB/cByJ substrain mice are highly susceptible to the induction of EAO whereas BALB/cJ mice are resistant. BALB/cJ mice have been reported to have elevated levels of serum T, which may account for disease resistance in light of its purported immunosuppressive effects. Serum T levels were determined by radioimmunoassay on 40 BALB/cByJ and 41 BALB/cJ age matched male mice. Our results indicate that the two substrains do not differ significantly from each other in their mean serum T levels (BALB/cByJ-4.50 ng/ml and BALB/cJ-3.16 ng/ml; p = 0.601) suggesting that the EAO resistant phenotype exhibited by BALB/cJ mice is not a result of the immunosuppressive effects of T.
BALB/cByJ亚系小鼠对实验性自身免疫性葡萄膜炎（EAO）的诱导高度敏感，而BALB/cJ小鼠具有抗性。据报道，BALB/cJ小鼠血清睾酮（T）水平升高，鉴于其所谓的免疫抑制作用，这可能是其抗病的原因。通过放射免疫分析法测定了40只年龄匹配的BALB/cByJ雄性小鼠和41只BALB/cJ雄性小鼠的血清T水平。我们的结果表明，这两个亚系的平均血清T水平没有显著差异（BALB/cByJ为4.50纳克/毫升，BALB/cJ为3.16纳克/毫升；p = 0.601），这表明BALB/cJ小鼠表现出的EAO抗性表型不是T免疫抑制作用的结果。
