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低血糖意识障碍:低血糖意识障碍患者的挑战、诱因和建议:病例报告。

Hypoglycemic unawareness: challenges, triggers, and recommendations in patients with hypoglycemic unawareness: a case report.

机构信息

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, First Floor, No 10, Jalal-Al-Ahmad Street, North Kargar Avenue, Tehran, 14117-13137, Iran.

Radiology Department, Iran University of Medical Sciences, Tehran, Iran.

出版信息

J Med Case Rep. 2022 Jul 21;16(1):283. doi: 10.1186/s13256-022-03498-1.

DOI:10.1186/s13256-022-03498-1
PMID:35858952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9301883/
Abstract

BACKGROUND

Hypoglycemia is a fairly common complication in diabetic patients, particularly in those on insulin therapy. Hypoglycemia symptoms are classified into two types: autonomic and neuroglycopenic symptoms. If a person develops neuroglycopenic symptoms before the appearance of autonomic symptoms or is asymptomatic until blood sugar levels are very low, the patient will develop hypoglycemic unawareness (HU).

CASE PRESENTATION

A 25-year-old Iranian woman with HU presented with a severe hypoglycemic episode. This episode was characterized by loss of consciousness and focal neural deficits, which were unusual symptoms in the patient, who was a medical intern with type 1 diabetes and currently being treated with regular and NPH insulin.

CONCLUSIONS

Hypoglycemia is a common complication in diabetic patients receiving oral or insulin therapy. A patient who is unaware of their condition may experience severe and potentially fatal episodes. These incidents can negatively affect their daily lives as well as their careers and jobs. Hypoglycemia-associated autonomic failure is a possible cause for patients with multiple episodes of severe hypoglycemia. IThe use of a continuous glucose monitoring device with an alarm, if available, can be an excellent option for these patients.

摘要

背景

低血糖是糖尿病患者相当常见的并发症,尤其是接受胰岛素治疗的患者。低血糖症状分为两类:自主神经症状和神经低血糖症状。如果一个人在出现自主神经症状之前出现神经低血糖症状,或者血糖水平非常低时没有症状,那么患者就会出现低血糖意识障碍(HU)。

病例介绍

一名 25 岁的伊朗妇女因 HU 出现严重低血糖发作。此次发作的特点是意识丧失和局灶性神经缺陷,这在该名患有 1 型糖尿病的实习医生患者中是不常见的症状,她目前正在接受常规和 NPH 胰岛素治疗。

结论

低血糖是接受口服或胰岛素治疗的糖尿病患者的常见并发症。意识不到自身状况的患者可能会经历严重且可能致命的发作。这些事件会对他们的日常生活以及职业和工作产生负面影响。与低血糖相关的自主神经衰竭可能是多次严重低血糖发作患者的原因之一。如果有条件,使用带报警功能的连续血糖监测仪是这些患者的绝佳选择。

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本文引用的文献

1
6. Glycemic Targets: .6. 血糖目标: 。
Diabetes Care. 2020 Jan;43(Suppl 1):S66-S76. doi: 10.2337/dc20-S006.
2
Hypoglycaemia Awareness Restoration Programme for People with Type 1 Diabetes and Problematic Hypoglycaemia Persisting Despite Optimised Self-care (HARPdoc): protocol for a group randomised controlled trial of a novel intervention addressing cognitions.1 型糖尿病患者低血糖意识恢复方案(HARPdoc):一项针对认知问题的新型干预措施的群组随机对照试验方案
BMJ Open. 2019 Jun 16;9(6):e030356. doi: 10.1136/bmjopen-2019-030356.
3
Hypoglycemia incidence and awareness among insulin-treated patients with diabetes: the HAT study in Brazil.胰岛素治疗的糖尿病患者低血糖的发生率及认知情况:巴西的HAT研究
Diabetol Metab Syndr. 2018 Nov 21;10:83. doi: 10.1186/s13098-018-0379-5. eCollection 2018.
4
The burden of severe hypoglycemia in type 1 diabetes.1型糖尿病中严重低血糖的负担。
Curr Med Res Opin. 2018 Jan;34(1):171-177. doi: 10.1080/03007995.2017.1391079. Epub 2017 Nov 10.
5
Hypoglycemia: The neglected complication.低血糖:被忽视的并发症。
Indian J Endocrinol Metab. 2013 Sep;17(5):819-34. doi: 10.4103/2230-8210.117219.
6
Improved biomedical and psychological outcomes 1 year after structured education in flexible insulin therapy for people with type 1 diabetes: the U.K. DAFNE experience.1 型糖尿病患者接受灵活胰岛素治疗的结构化教育 1 年后,改善了生物医学和心理结局:英国 DAFNE 经验。
Diabetes Care. 2012 Aug;35(8):1638-42. doi: 10.2337/dc11-1579. Epub 2012 May 22.
7
Effect of continuous glucose monitoring on hypoglycemia in type 1 diabetes.连续血糖监测对 1 型糖尿病患者低血糖的影响。
Diabetes Care. 2011 Apr;34(4):795-800. doi: 10.2337/dc10-1989. Epub 2011 Feb 19.
8
Use of continuous glucose monitoring in the detection and prevention of hypoglycemia.持续血糖监测在低血糖检测与预防中的应用。
J Diabetes Sci Technol. 2007 Jan;1(1):146-50. doi: 10.1177/193229680700100126.
9
Hypoglycemia unawareness is associated with reduced adherence to therapeutic decisions in patients with type 1 diabetes: evidence from a clinical audit.低血糖无意识与1型糖尿病患者治疗决策依从性降低有关:一项临床审计的证据。
Diabetes Care. 2009 Jul;32(7):1196-8. doi: 10.2337/dc08-2259. Epub 2009 Apr 23.
10
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Diabetes Res Clin Pract. 2008 Aug;81(2):184-9. doi: 10.1016/j.diabres.2008.04.007. Epub 2008 May 20.