来曲唑联合尿促性腺激素治疗内分泌异常性不孕患者的排卵效果：一项回顾性单中心、病例对照研究。

Efficacy of Letrozole Combined with Urinary Gonadotropin for Ovulation Induction in Endocrine Abnormal Infertility Patients: A Retrospective Single-Center, Case-Control Study.

机构信息

Department of Obstetrics and Gynecology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Edong Healthcare Group, Huangshi, 435000 Hubei Province, China.

Department of Reproductive Medicine, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Edong Healthcare Group, Huangshi, 435000 Hubei Province, China.

出版信息

Comput Math Methods Med. 2022 Jul 11;2022:5363754. doi: 10.1155/2022/5363754. eCollection 2022.

DOI:10.1155/2022/5363754

PMID:35860181

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9293500/

Abstract

AIMS

To ask lots of questions and try to find the truth about the medicine-based effectiveness of letrozole (LE) combined with human menopausal gonadotropin (HMG) in the treatment of inability to have children crops patients with endocrine (things that are different from what is usually expected and the effect on ovulation-related chemicals produced by the body).

MATERIALS AND METHODS

A total of 160 unable to have children crops patients with endocrine things that are different from what is usually expected who were treated in our hospital from March 2019 to March 2022 were selected as the subjects of this look at how things were in the past study and were divided into instance of watching, making a statement group was treated with human menopausal gonadotropin on the basis of the control group. The differences in serum related to the process of making children, chemical produced by the body levels, ovarian function, and ovulation induction effect between the two groups were watched and compared.

RESULTS

After treatment, LH, FSH, PRL, and E in the observation group were better than those in the control group. The ovarian volume, follicle size, follicle diameter, and endometrial thickness of the two groups of patients were significantly improved, and the observation group was better than the control group. Significance is < 0.05. After treatment, the ovarian volume, follicle size, follicle diameter, and endometrial thickness in the two groups were significantly improved, and the observation group was better than the control group, and the difference was statistically significant ( < 0.05). The ovulation rate, pregnancy rate, singleton pregnancy rate, and multiple pregnancy rate of the observation group were higher than those of the control group, and the difference was statistically significant by the chi-square test ( < 0.05).

CONCLUSION

Letrozole can promote the improvement of sex hormones in infertile patients. After being combined with human menopausal gonadotropin treatment, the follicle development and ovulation of patients are significantly improved, and infertility is improved to a certain extent. It has a certain reference value in the clinical treatment of endocrine abnormal infertility.

摘要

目的

提出大量问题，试图寻找有关来曲唑（LE）联合人绝经期促性腺激素（HMG）治疗内分泌性不孕患者的药物疗效的真相。

材料和方法

选择 2019 年 3 月至 2022 年 3 月在我院治疗的 160 例内分泌性不孕患者作为本研究对象，并将其分为观察组和对照组，每组 80 例。对照组患者采用人绝经期促性腺激素进行治疗，观察组患者在对照组治疗的基础上加用来曲唑进行治疗。观察并比较两组患者血清相关生殖化学物质水平、卵巢功能、排卵诱导效果的差异。

结果

治疗后，观察组患者的 LH、FSH、PRL 和 E 水平均优于对照组，两组患者的卵巢体积、卵泡大小、卵泡直径和子宫内膜厚度均明显改善，观察组明显优于对照组，差异具有统计学意义（ < 0.05）。治疗后，两组患者的卵巢体积、卵泡大小、卵泡直径和子宫内膜厚度均明显改善，观察组明显优于对照组，差异具有统计学意义（ < 0.05）。观察组患者的排卵率、妊娠率、单胎妊娠率和多胎妊娠率均高于对照组，差异具有统计学意义（ < 0.05）。