Plácido Ana Isabel, Aguiar Ana, Piñeiro-Lamas María, Varallo Fabiana, Figueiras Adolfo, Herdeiro Maria Teresa, Roque Fátima
Research Unit for Inland Development, Polytechnic of Guarda (UDI-IPG), Guarda, Portugal.
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Madrid, Spain.
Risk Manag Healthc Policy. 2022 Jul 13;15:1343-1352. doi: 10.2147/RMHP.S346300. eCollection 2022.
Prescription of potentially inappropriate medication (PIM) in older adults is associated with poor clinical outcomes. The EU (7)-PIM list was created for the European market to improve pharmacotherapy in older adults.
This work aims to characterize the medication profile and assess the presence of PIM, using the EU (7)-PIM list in older adults' residents at nursing homes.
Retrospective data were collected from the anonymized nursing home records. After PIM identification, a descriptive analysis was performed, and a generalized linear model for dependent negative binomial-type variables was constructed to assess the risk of PIM.
Of the 210 participants (mean age 85.10), 82.40% were polymedicated. PIM was observed in 86.4% participants (mean per patient = 2.30± 0.10). The most common PIM were proton pump inhibitors (n = 121, 57.62%), followed by anxiolytics (n = 96, 45.71%). 64.30% of all patients take 2-4 PIM and 5.80% take five or more PIM. The occurrence of PIM is influenced by the number of prescribed medicines (RR 1.14; 95% CI 1.1.-1.17) and the presence of digestive system diseases (RR 1.05; 95% CI 1.0-1.09).
The high prevalence of PIM observations highlights the necessity of the implementation of guidelines to prevent PIM.
老年人使用潜在不适当药物（PIM）与不良临床结局相关。欧盟（7）-PIM清单是为欧洲市场制定的，旨在改善老年人的药物治疗。
本研究旨在利用欧盟（7）-PIM清单描述养老院老年居民的用药情况并评估PIM的存在情况。
从匿名的养老院记录中收集回顾性数据。识别出PIM后，进行描述性分析，并构建依赖负二项式类型变量的广义线性模型来评估PIM的风险。
在210名参与者（平均年龄85.10岁）中，82.40%的人使用多种药物。86.4%的参与者中观察到PIM（每位患者平均 = 2.30±0.10）。最常见的PIM是质子泵抑制剂（n = 121，57.62%），其次是抗焦虑药（n = 96，45.71%）。所有患者中有64.30%服用2-4种PIM，5.80%服用五种或更多PIM。PIM的发生受所开药物数量（RR 1.14；95% CI 1.1.-1.17）和消化系统疾病的存在（RR 1.05；95% CI 1.0-1.09）影响。
PIM观察的高发生率凸显了实施预防PIM指南的必要性。
