Yagita Yoshiki
Department of Stroke Medicine, Kawasaki Medical School.
Brain Nerve. 2022 Jul;74(7):905-909. doi: 10.11477/mf.1416202146.
Thrombosis with thrombocytopenia syndrome (TTS) induced by the coronavirus disease 2019 vaccine is characterized by thrombocytopenia and thrombosis. Positivity for the anti-platelet factor 4-antibody is related to TTS pathophysiology, similar to heparin-induced thrombocytopenia. Although TTS is very rare, with an incidence of almost 1/100,000 cases, physicians need to keep in mind this adverse reaction that can lead to serious symptoms and death. Prompt treatment should be initiated in cases of suspected TTS.
2019冠状病毒病疫苗诱导的血栓形成伴血小板减少综合征(TTS)的特征是血小板减少和血栓形成。抗血小板因子4抗体阳性与TTS的病理生理学有关,类似于肝素诱导的血小板减少症。尽管TTS非常罕见,发病率几乎为十万分之一,但医生需要牢记这种可能导致严重症状和死亡的不良反应。疑似TTS病例应立即开始治疗。