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Rheumatology (Oxford). 2023 Feb 1;62(2):492-494. doi: 10.1093/rheumatology/keac418.
2
Autophagy is activated in systemic lupus erythematosus and required for plasmablast development.自噬在系统性红斑狼疮中被激活，并且是浆母细胞发育所必需的。
Ann Rheum Dis. 2015 May;74(5):912-20. doi: 10.1136/annrheumdis-2013-204343. Epub 2014 Jan 13.
3
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Signaling Lymphocytic Activation Molecule Family Member 1 Engagement Inhibits T Cell-B Cell Interaction and Diminishes Interleukin-6 Production and Plasmablast Differentiation in Systemic Lupus Erythematosus.信号淋巴细胞激活分子家族成员 1 结合抑制 T 细胞 -B 细胞相互作用，并减少系统性红斑狼疮中白细胞介素-6 的产生和浆母细胞分化。
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Methionine Commits Cells to Differentiate Into Plasmablasts Through Epigenetic Regulation of BTB and CNC Homolog 2 by the Methyltransferase EZH2.蛋氨酸通过甲基转移酶 EZH2 对 BTB 和 CNC 同源物 2 的表观遗传调控使细胞分化为浆母细胞。
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The suppression of Brd4 inhibits peripheral plasma cell differentiation and exhibits therapeutic potential for systemic lupus erythematosus.Brd4 抑制物抑制外周浆细胞分化，并具有治疗系统性红斑狼疮的潜力。
Int Immunopharmacol. 2022 Feb;103:108498. doi: 10.1016/j.intimp.2021.108498. Epub 2021 Dec 28.
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UBE2L3 regulates TLR7-induced B cell autoreactivity in Systemic Lupus Erythematosus.泛素结合酶E2L3调节系统性红斑狼疮中Toll样受体7诱导的B细胞自身反应性。
J Autoimmun. 2023 Apr;136:103023. doi: 10.1016/j.jaut.2023.103023. Epub 2023 Mar 29.

本文引用的文献

1
Combined plasma metabolomic and transcriptomic analysis identify histidine as a biomarker and potential contributor in SLE pathogenesis.联合血浆代谢组学和转录组学分析确定组氨酸是系统性红斑狼疮发病机制中的一种生物标志物和潜在促成因素。
Rheumatology (Oxford). 2023 Feb 1;62(2):905-913. doi: 10.1093/rheumatology/keac338.
2
Longitudinal Immune Cell Profiling in Patients With Early Systemic Lupus Erythematosus.早期系统性红斑狼疮患者的纵向免疫细胞分析。
Arthritis Rheumatol. 2022 Nov;74(11):1808-1821. doi: 10.1002/art.42248. Epub 2022 Oct 7.
3
Immune cell multiomics analysis reveals contribution of oxidative phosphorylation to B-cell functions and organ damage of lupus.免疫细胞多组学分析揭示氧化磷酸化对 B 细胞功能和狼疮器官损伤的贡献。
Ann Rheum Dis. 2022 Jun;81(6):845-853. doi: 10.1136/annrheumdis-2021-221464. Epub 2022 Mar 2.
4
An enhanced mitochondrial function through glutamine metabolism in plasmablast differentiation in systemic lupus erythematosus.通过谷氨酰胺代谢增强线粒体功能在系统性红斑狼疮中浆母细胞分化。
Rheumatology (Oxford). 2022 Jul 6;61(7):3049-3059. doi: 10.1093/rheumatology/keab824.
5
Precision medicine in autoimmune diseases: fact or fiction.精准医学与自身免疫性疾病：现实还是虚构？
Rheumatology (Oxford). 2021 Sep 1;60(9):3977-3985. doi: 10.1093/rheumatology/keab448.
6
Targeting mitochondrial oxidative stress with MitoQ reduces NET formation and kidney disease in lupus-prone MRL- mice.靶向线粒体氧化应激的 MitoQ 可减少狼疮易感 MRL- 小鼠的 NET 形成和肾脏疾病。
Lupus Sci Med. 2020 Apr;7(1). doi: 10.1136/lupus-2020-000387. Epub 2020 Apr 16.
7
Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients.个性化免疫监测揭示了对狼疮患者进行分层的分子网络。
Cell. 2016 Apr 21;165(3):551-65. doi: 10.1016/j.cell.2016.03.008. Epub 2016 Mar 31.
8
Increased mitochondrial electron transport chain activity at complex I is regulated by N-acetylcysteine in lymphocytes of patients with systemic lupus erythematosus.N-乙酰半胱氨酸可调节系统性红斑狼疮患者淋巴细胞中线粒体电子传递链复合物 I 的活性。
Antioxid Redox Signal. 2014 Jul 1;21(1):56-65. doi: 10.1089/ars.2013.5702. Epub 2014 Apr 23.
9
Autophagy is activated in systemic lupus erythematosus and required for plasmablast development.自噬在系统性红斑狼疮中被激活，并且是浆母细胞发育所必需的。
Ann Rheum Dis. 2015 May;74(5):912-20. doi: 10.1136/annrheumdis-2013-204343. Epub 2014 Jan 13.

'What is fuelling the immune response in systemic lupus erythematosus?' Evaluating the key metabolites driving plasmablast differentiation.

作者信息

Wincup Chris, Fasano Serena

机构信息

Department of Rheumatology, Division of Medicine, Rayne Building, University College London.

Department of Rheumatology, King's College Hospital, London, UK.

出版信息

Rheumatology (Oxford). 2023 Feb 1;62(2):492-494. doi: 10.1093/rheumatology/keac418.

DOI:10.1093/rheumatology/keac418
PMID:35861392
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9891419/
Abstract
摘要