Narcotic analysis section, Seoul Institute of National Forensic Service, 139 Jiyangro, Yangcheungu, Seoul 08036, South Korea.
Forensic toxicology division, National Forensic Service, 10 Ipchunro, Wonju 26460, South Korea.
Forensic Sci Int. 2022 Sep;338:111385. doi: 10.1016/j.forsciint.2022.111385. Epub 2022 Jul 13.
A wide variety of new synthetic cannabinoids have emerged around the world in recent years, and because of this rapid emergence, the detection and monitoring of this class of abused drugs remain a challenge. In this study, a new cannabimimetic indazole-3-carboxamide derivative, N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)- 5-bromo-1 H-indazole-3-carboxamide, was identified from seized e-cigarette liquid samples and newly named as ADB-BRINACA by referring to the names of other known indazole-class synthetic cannabinoids. Structure identification was accomplished based on gas chromatography-mass spectrometry (GC-MS), high-performance liquid chromatography-high resolution quadrupole mass spectrometry (HPLC-QTOF-MS/MS), and nuclear magnetic resonance spectrometry (NMR). The concentration range of ADB-BRINACA in six e-cigarette liquid samples was found to be 2228-4203 mg/L using ERETIC 2, a quantitative NMR method, which is advantageous in the absence of a reference material. As there have been no chemical or pharmaceutical reports on ADB-BRINACA until now, this is the first report presenting a comprehensive analytical characterization of ADB-BRINACA.
近年来，世界各地出现了多种新型合成大麻素，由于这种快速出现，检测和监测这类滥用药物仍然是一个挑战。在这项研究中，从缉获的电子烟液样本中鉴定出一种新型大麻素吲唑-3-甲酰胺衍生物，N-(1-氨基-3,3-二甲基-1-氧代丁-2-基)-5-溴-1H-吲唑-3-甲酰胺，并根据其他已知吲唑类合成大麻素的名称将其重新命名为 ADB-BRINACA。结构鉴定是基于气相色谱-质谱联用（GC-MS）、高效液相色谱-高分辨率四极杆质谱联用（HPLC-QTOF-MS/MS）和核磁共振波谱（NMR）完成的。使用 ERETIC 2（一种定量 NMR 方法），在没有参考物质的情况下，在六个电子烟液样本中发现 ADB-BRINACA 的浓度范围为 2228-4203mg/L。由于到目前为止还没有关于 ADB-BRINACA 的化学或药物报告，这是首次全面分析表征 ADB-BRINACA 的报告。
