追求速度：在狭小空间中迁移的细胞会加快分子钟的运转。
The need for speed: Migratory cells in tight spaces boost their molecular clock.
机构信息
School of Engineering, Center for Biomedical Engineering, and Legoretta Cancer Center, Brown University, Providence, RI 02912, USA.
School of Engineering, Center for Biomedical Engineering, and Legoretta Cancer Center, Brown University, Providence, RI 02912, USA.
出版信息
Cell Syst. 2022 Jul 20;13(7):509-511. doi: 10.1016/j.cels.2022.06.002.
Abstract
Cells migrating in spatial confinement exhibit higher intracellular calcium levels, which increases the oscillation frequency of a "molecular clock" that synchronizes guanine nucleotide exchange factor GEF-H1 and microtubule polymerization for more frequent bursts of speed.
摘要
细胞在空间限制下迁移时表现出更高的细胞内钙离子水平，这增加了“分子钟”的振荡频率，使鸟嘌呤核苷酸交换因子 GEF-H1 和微管聚合更加频繁地爆发速度。
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