Ridley Anne J, Schwartz Martin A, Burridge Keith, Firtel Richard A, Ginsberg Mark H, Borisy Gary, Parsons J Thomas, Horwitz Alan Rick
Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London W1W 7BS, UK.
Science. 2003 Dec 5;302(5651):1704-9. doi: 10.1126/science.1092053.
Cell migration is a highly integrated multistep process that orchestrates embryonic morphogenesis; contributes to tissue repair and regeneration; and drives disease progression in cancer, mental retardation, atherosclerosis, and arthritis. The migrating cell is highly polarized with complex regulatory pathways that spatially and temporally integrate its component processes. This review describes the mechanisms underlying the major steps of migration and the signaling pathways that regulate them, and outlines recent advances investigating the nature of polarity in migrating cells and the pathways that establish it.
细胞迁移是一个高度整合的多步骤过程，它协调胚胎形态发生；有助于组织修复和再生；并推动癌症、智力迟钝、动脉粥样硬化和关节炎等疾病的进展。迁移细胞具有高度极化性，其复杂的调控途径在空间和时间上整合其组成过程。本文综述了迁移主要步骤的潜在机制及其调控信号通路，并概述了研究迁移细胞极性本质及其建立途径的最新进展。
