Ashizawa K, Matsuo K, Taguchi H, Maeda J, Tsuchiyama H
Gan No Rinsho. 1987 Mar;33(3):317-21.
A rare case of malignant mesenchymoma in a 58-year-old woman is described. The tumor grew rapidly for a month and was located in the mesosigmoid. The resected tumor measured 25 X 20 X 20 cm and weighed 5,000 g. It metastasized into the great omentum within four months after operation. Histologically, this tumor was composed of undifferentiated sarcomatous elements, but in some parts revealed patterns of differentiation, including leiomyosarcoma, chondrosarcoma and osteosarcoma. In areas of osteosarcoma, the bone tissue varied from immature to mature. The histology of the recurrent tumors was similar to that of the first tumor. We considered that undifferentiated sarcomatous elements contained pluripotential cells which could differentiate multiple, mature malignant mesenchymes.
本文描述了一例58岁女性的罕见恶性间叶瘤病例。肿瘤在一个月内迅速生长,位于乙状结肠系膜。切除的肿瘤大小为25×20×20厘米,重5000克。术后四个月内转移至大网膜。组织学上,该肿瘤由未分化的肉瘤成分组成,但在某些部位显示出分化模式,包括平滑肌肉瘤、软骨肉瘤和骨肉瘤。在骨肉瘤区域,骨组织从不成熟到成熟不等。复发性肿瘤的组织学与第一个肿瘤相似。我们认为未分化的肉瘤成分包含多能细胞,这些细胞可以分化为多种成熟的恶性间叶组织。