Miao Xiaomei, Wu Hongying, Liu Yan, Zhang Shu, Li Chaohui, Hao Jie
National Physician Hall, Cangzhou Central Hospital, Cangzhou, China.
Department of Hepatopancreatobiliary Surgery, Cangzhou Central Hospital, Cangzhou, China.
J Oncol. 2022 Jul 12;2022:6156585. doi: 10.1155/2022/6156585. eCollection 2022.
To assess the clinical efficacy of acupuncture on neoadjuvant chemotherapy with capecitabine plus paclitaxel and radiotherapy in progressive gastric cancer.
In this randomized, double-blind, controlled clinical trial, 70 patients with advanced gastric cancer receiving radio-chemotherapy between May 2018 and June 2020 were assessed for eligibility in our institution and recruited. They were assigned via the random number table method at a ratio of 1 : 1 to receive either neoadjuvant chemotherapy with capecitabine plus paclitaxel and radiotherapy (control group) or acupuncture on neoadjuvant chemotherapy with capecitabine plus paclitaxel and radiotherapy (intervention group). The outcome measures included symptom mitigation, quality of life, and traditional Chinese medicine (TCM) symptom scores.
The two groups showed similar results in abdominal circumference, intraabdominal pressure, and bowel sounds before treatment ( > 0.05). Acupuncture plus conventional treatment was associated with better mitigation on intraabdominal pressure (11.08 ± 1.37 vs. 12.17 ± 2.68) and bowel sounds (4 [3, 4] vs. 3 [3, 4]) versus conventional treatment alone ( < 0.05). No statistically significant difference in TCM symptom scores was observed between the two groups before treatment ( > 0.05). Acupuncture plus conventional treatment resulted in a lower TCM symptom score (24.63 ± 4.56 points) versus conventional treatment (31.17 ± 4.91 points) ( < 0.05). The eligible patients given acupuncture showed significantly higher scores of physical function, role function, emotional function, cognitive function, and social function (81.52 ± 5.37, 88.17 ± 5.17, 85.15 ± 6.71, 78.45 ± 5.85, and 80.98 ± 7.14) versus those without acupuncture (52.98 ± 8.23, 69.87 ± 5.54, 68.24 ± 9.22, 61.34 ± 6.27, and 64.79 ± 6.89) ( < 0.05).
Acupuncture is effective in the recovery of acute toxicity after radio-chemotherapy for patients with advanced gastric cancer, which provides a certain reference for clinical treatment and is worthy of application and promotion.
评估针刺联合卡培他滨加紫杉醇新辅助化疗及放疗对进展期胃癌的临床疗效。
在这项随机、双盲、对照临床试验中，对2018年5月至2020年6月期间在我院接受放化疗的70例晚期胃癌患者进行资格评估并招募。通过随机数字表法将他们按1∶1的比例分配，分别接受卡培他滨加紫杉醇新辅助化疗及放疗（对照组）或针刺联合卡培他滨加紫杉醇新辅助化疗及放疗（干预组）。观察指标包括症状缓解情况、生活质量和中医症状评分。
两组治疗前腹围、腹内压和肠鸣音结果相似（P>0.05）。与单纯常规治疗相比，针刺联合常规治疗在腹内压（11.08±1.37 vs. 12.17±2.68）和肠鸣音（4[3,4] vs. 3[3,4]）方面缓解更好（P<0.05）。两组治疗前中医症状评分差异无统计学意义（P>0.05）。与常规治疗相比，针刺联合常规治疗的中医症状评分更低（24.63±4.56分 vs. 31.17±4.91分）（P<0.05）。接受针刺治疗的合格患者在身体功能、角色功能、情感功能、认知功能和社会功能方面的得分显著高于未接受针刺治疗的患者（81.52±5.37、88.17±5.17、85.15±6.71、78.45±5.85和80.98±7.14）（52.98±8.23、69.87±5.54、68.24±9.22、61.34±6.27和64.79±6.89）（P<0.05）。
针刺对晚期胃癌患者放化疗后急性毒性反应的恢复有效，为临床治疗提供了一定参考，值得应用推广。
