Pericleous Stephanos, Doran Sophie L F, Wotherspoon Andrew, Terlizzo Monica, Riddell Angela, Brown Gina, Shur Joshua, Chua Sue, Hujairi Nabil, Middleton Nicos, Cunningham David, Kumar Sacheen, Bhogal Ricky H
Department of HPB Surgery, Academic Department of Surgery, Royal Marsden Hospital, London, United Kingdom.
Department of Histopathology, Royal Marsden Hospital, London, United Kingdom.
World J Nucl Med. 2022 Jul 19;21(2):112-119. doi: 10.1055/s-0042-1750332. eCollection 2022 Jun.
Gallbladder cancer has a poor prognosis and imaging can have variable diagnostic accuracy. We assessed the ability of preoperative F-fluorodeoxyglucose positron emission tomography computed tomography ( F-FDG-PET/CT) imaging to predict a postoperative histological diagnosis of gallbladder cancer. A retrospective analysis was undertaken in a cohort of patients, who had suspected gallbladder cancer on cross-sectional imaging and that underwent preoperative FDG-PET/CT scan. The discriminatory power of FDG-PET/CT was determined in receiver operator characteristic (ROC) analysis and diagnostic accuracy parameters were estimated at different thresholds of maximum standard unit value (SUV ) Twenty-two patients were included in the study; 7 had malignant and 15 benign diagnoses. There was no statistically significant difference between the measured SUV between the two groups ( = 0.71). With an area under the curve of 0.486, the ROC curve did not indicate any discriminatory power of FDG-PET/CT at any potential threshold of SUV This study indicates that the diagnosis of primary gallbladder cancer cannot be accurately confirmed with FDG PET/CT scanning.
胆囊癌预后较差，影像学诊断准确性存在差异。我们评估了术前氟脱氧葡萄糖正电子发射断层扫描计算机断层扫描（F-FDG-PET/CT）成像预测胆囊癌术后组织学诊断的能力。
对一组经横断面成像怀疑患有胆囊癌且接受术前FDG-PET/CT扫描的患者进行了回顾性分析。在受试者操作特征（ROC）分析中确定了FDG-PET/CT的鉴别能力，并在最大标准摄取值（SUV）的不同阈值下估计诊断准确性参数。
该研究纳入了22例患者；7例诊断为恶性，15例诊断为良性。两组间测量的SUV无统计学显著差异（P = 0.71）。ROC曲线下面积为0.486，表明在任何潜在的SUV阈值下，FDG-PET/CT均无鉴别能力。
本研究表明，FDG PET/CT扫描不能准确确诊原发性胆囊癌。
