甘露醇联合6-氨基己酸治疗脑出血患者的疗效及其对免疫功能的影响
The Efficacy of Mannitol Combined with 6-Aminocaproic Acid in the Treatment of Patients with Cerebral Hemorrhage and Its Impact on Immune Function.
作者信息
Tian Buxian, Tian Bohan, Zhang Yuhong
机构信息
Department of Neurology, First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, Liaoning, China.
Class 2017 imaging department, Jinzhou Medical University, Jinzhou 121001, Liaoning, China.
出版信息
Evid Based Complement Alternat Med. 2022 Jul 12;2022:7396310. doi: 10.1155/2022/7396310. eCollection 2022.
OBJECTIVE
To determine the efficacy of Mannitol combined with 6-aminocaproic acid in the treatment of patients with cerebral hemorrhage, as well as its impact on the immune system.
METHODS
The study subjects consisted of 122 patients with early intracerebral hemorrhage treated in our hospital from April 2019 to April 2022. Based on the different admission times, the participants were randomly divided into the control group and the study group in a ratio of 1:1. 6-Aminocaproic acid was used to treat patients in the control group, while Mannitol along with 6-aminocaproic acid was used to treat patients in the study group. Short form-36 health survey (SF-36) scores, hematoma volume changes, National Institutes of Health Stroke Scale (NIHSS), and Mini-Mental State Examination (MMSE) scores, clinical efficacy, and changes in the immune function in patients from the two groups were analyzed and compared.
RESULTS
The total efficacy of treatment in the study group was significantly higher than that in the control group ( = 9,375, < 0.001). Patients in the study group had significantly higher scores in social function, mental health, physical function, and physiological function compared to those in the control group ( < 0.05). After treatment, there was a significant reduction in NIHSS scores in patients from both groups, but a greater reduction was seen in patients from the study group ( < 0.05). After 2 weeks of treatment, the volume of cerebral edema was significantly smaller in patients from the study group than in those from the control group ( < 0.05). Before treatment, there was no significant difference in the number of CD4+ and CD8+ T lymphocytes between patients in the two groups. However, after treatment, patients in the study group had higher numbers of CD4+ T lymphocytes and lower numbers of CD8+ T lymphocytes compared to those in the control group ( < 0.05).
CONCLUSIONS
The combination of Mannitol and 6-aminocaproic acid appears to be very efficacious in the treatment of cerebral hemorrhage. It improves immune function, reduces neurological damage, and minimizes the volume of cerebral edema.
目的
探讨甘露醇联合6-氨基己酸治疗脑出血患者的疗效及其对免疫系统的影响。
方法
选取2019年4月至2022年4月在我院治疗的122例早期脑出血患者作为研究对象。根据入院时间不同，将患者按1:1比例随机分为对照组和研究组。对照组采用6-氨基己酸治疗，研究组采用甘露醇联合6-氨基己酸治疗。分析比较两组患者的36条目简明健康状况调查量表（SF-36）评分、血肿体积变化、美国国立卫生研究院卒中量表（NIHSS）及简易精神状态检查表（MMSE）评分、临床疗效和免疫功能变化。
结果
研究组的总治疗有效率显著高于对照组（χ² = 9.375，P < 0.001）。研究组患者的社会功能、心理健康、身体功能和生理功能得分显著高于对照组（P < 0.05）。治疗后，两组患者的NIHSS评分均显著降低，但研究组患者的降低幅度更大（P < 0.05）。治疗2周后，研究组患者的脑水肿体积显著小于对照组（P < 0.05）。治疗前，两组患者的CD4⁺和CD8⁺T淋巴细胞数量无显著差异。然而，治疗后，研究组患者的CD4⁺T淋巴细胞数量高于对照组，CD8⁺T淋巴细胞数量低于对照组（P < 0.05）。
结论
甘露醇联合6-氨基己酸治疗脑出血似乎非常有效。它可改善免疫功能，减少神经损伤，并使脑水肿体积最小化。
Zotero 插件