Attia Khalid A M, Abdel-Monem Ahmed H, Ashmawy Ashraf M, Eissa Amr S, Abdel-Raoof Ahmed M
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University 11751 Nasr City Cairo Egypt
Chemistry Department, Faculty of Science, Al-Azhar University Nasr City Cairo 11884 Egypt.
RSC Adv. 2022 Jun 30;12(30):19133-19143. doi: 10.1039/d2ra02685f. eCollection 2022 Jun 29.
A new sensor for alogliptin benzoate (ALG) estimation based on a simple and sensitive method was evolved on multiwalled-carbon-nanotube modified nanocrystalline zinc chromite carbon paste electrodes (ZnCrO@MWCNTs/CPEs). ALG electrochemical behavior was evaluated using a cyclic voltammetry (CV), square wave voltammetry (SWV) and chronoamperometry (CA). The new electrode materials were characterized by scanning electron microscope (SEM), transmission electron microscope (TEM), energy dispersive X-ray analysis (EDX) for elemental analysis and mapping, and X-ray diffraction (XRD) and the X-ray photoelectron spectroscopy (XPS) measurements. All these measurements exhibiting enhanced activity and high conductivity compared to the bare electrode without modification. The calibration curves obtained for ALG were in the ranges of 0.1-20 μmol L with a quantification and detection limits of 0.09 and 0.03 μmol L, respectively. The prepared sensor showed a good sensitivity and selectivity with less over potential for ALG determination. Finally, the presented method was successfully applied as a simple, precise and selective electrochemical electrode for the estimation of ALG in its pharmaceutical dosage form.
基于一种简单且灵敏的方法，在多壁碳纳米管修饰的纳米晶亚铬酸锌碳糊电极（ZnCrO@MWCNTs/CPEs）上开发了一种用于苯甲酸阿格列汀（ALG）测定的新型传感器。使用循环伏安法（CV）、方波伏安法（SWV）和计时电流法（CA）评估了ALG的电化学行为。通过扫描电子显微镜（SEM）、透射电子显微镜（TEM）、用于元素分析和映射的能量色散X射线分析（EDX）以及X射线衍射（XRD）和X射线光电子能谱（XPS）测量对新型电极材料进行了表征。与未修饰的裸电极相比，所有这些测量均显示出增强的活性和高导电性。ALG获得的校准曲线范围为0.1 - 20 μmol/L，定量限和检测限分别为0.09和0.03 μmol/L。所制备的传感器对ALG测定显示出良好的灵敏度和选择性，过电位较小。最后，所提出的方法成功地作为一种简单、精确且选择性的电化学电极用于其药物剂型中ALG的测定。
