Shiomi M, Ito T, Watanabe Y
Lab Anim Sci. 1987 Feb;37(1):84-8.
The homozygous Watanabe heritable hyperlipidemic (WHHL) rabbit, an animal model for human familial hypercholesterolemia, which has been maintained in a closed colony, has a reproductive ability which is remarkably lower than that of normal rabbits. The present study was undertaken to determine whether this low reproductive ability was associated with hyperlipidemia, since it is not associated with inbreeding depression. WHHL dams with over 600 mg/dl of serum cholesterol level showed a weaning rate of only about 20%, while dams with about 300 mg/dl of cholesterol showed a 64% weaning rate. Both conception and weaning rate seemed to decrease with a rise in serum triglyceride. The weaning age of homozygous offspring from the homozygous WHHL dams was significantly higher than homozygous offspring from heterozygous WHHL dame. The rate of increase in body weight of the offspring from WHHL dams was significantly lower than that of the offspring from heterozygous dams under 24 days of age. We concluded that the low reproductive ability, especially low nursing ability, was associated with hyperlipidemia due to the deficiency of low density lipoprotein receptors.
纯合子渡边遗传性高脂血症（WHHL）兔是人类家族性高胆固醇血症的动物模型，一直在封闭群体中饲养，其繁殖能力明显低于正常兔。本研究旨在确定这种低繁殖能力是否与高脂血症有关，因为它与近亲繁殖衰退无关。血清胆固醇水平超过600mg/dl的WHHL母兔的断奶率仅约为20%，而胆固醇水平约为300mg/dl的母兔的断奶率为64%。受孕率和断奶率似乎都随着血清甘油三酯的升高而降低。纯合子WHHL母兔的纯合子后代的断奶年龄显著高于杂合子WHHL母兔的纯合子后代。在24日龄以下，WHHL母兔后代的体重增加率显著低于杂合子母兔的后代。我们得出结论，低繁殖能力，尤其是低哺育能力，与低密度脂蛋白受体缺乏导致的高脂血症有关。
