Bunce G E, Vessal M
J Steroid Biochem. 1987 Mar;26(3):303-8. doi: 10.1016/0022-4731(87)90093-8.
A deficiency of vitamin B6 has been reported to enhance oestrogen responsiveness of the uterus in rats whereas zinc deficiency provokes a syndrome suggestive of a diminution in oestrogen sensitivity. In this study [3H]oestrogen uptake by the uterus was increased in rats deficient in either nutrient and the differences were additive in the dually deficient animals. The total number of oestrogen receptors per g tissue was unaffected by either nutrient but the proportion of the receptors recovered from the nuclear fraction increased from about 6 to 74% when both nutrients were withheld. The results are consistent with the hypothesis that both zinc and pyridoxal phosphate play important metabolic roles in end-organ responsiveness to oestrogen.
据报道，维生素B6缺乏会增强大鼠子宫对雌激素的反应性，而锌缺乏会引发一种提示雌激素敏感性降低的综合征。在本研究中，缺乏任何一种营养素的大鼠子宫对[3H]雌激素的摄取均增加，并且在双重缺乏的动物中，这种差异具有累加性。每克组织中雌激素受体的总数不受任何一种营养素的影响，但当两种营养素都缺乏时，从核部分回收的受体比例从约6%增加到74%。这些结果与锌和磷酸吡哆醛在终末器官对雌激素的反应中都发挥重要代谢作用的假设一致。
