Pillay D, Gathiram P, Ubbink J B
Department of Human Physiology and Physiological Chemistry, University of Durban-Westville, Durban, South Africa.
Int J Vitam Nutr Res. 1997;67(1):22-6.
Three groups of young male Wistar rats were maintained on diets consisting of 7 mg pyridoxine hydrochloride/kg diet (control and pair-fed groups) and 0 mg pyridoxine hydrochloride/ kg diet (deficient group) for six weeks. The zinc status of all rats was assessed by measuring their erythrocyte zinc-metallothionein-1 (Zn-Mt-1) and plasma zinc levels. A significant difference (p < 0.001) in plasma zinc levels was observed between the deficient group and the control and pair-fed groups (1.35 micrograms/ml +/- 0.08, 1.99 micrograms/ml +/- 0.06 and 2.03 micrograms/ml +/- 0.07 respectively). Erythrocyte Zn-Mt-1 levels were significantly lower in vitamin B6 deficient rats when compared to control animals. No significant difference in Zn-Mt-1 levels existed between vitamin B6 deficient and pair-fed groups suggesting that the reduced Zn-Mt-1 levels in vitamin B6 deficient rats may be due entirely to their decreased food intake (8.9 g/day compared to 15 g/day of control rats).
将三组年轻雄性Wistar大鼠分别喂食含7毫克盐酸吡哆醇/千克饲料的日粮（对照组和配对喂养组）和不含盐酸吡哆醇的日粮（缺乏组），持续六周。通过测量所有大鼠的红细胞锌金属硫蛋白-1（Zn-Mt-1）水平和血浆锌水平来评估它们的锌状态。缺乏组与对照组和配对喂养组之间的血浆锌水平存在显著差异（p < 0.001）（分别为1.35微克/毫升±0.08、1.99微克/毫升±0.06和2.03微克/毫升±0.07）。与对照动物相比，维生素B6缺乏的大鼠红细胞Zn-Mt-1水平显著降低。维生素B6缺乏组和配对喂养组之间的Zn-Mt-1水平没有显著差异，这表明维生素B6缺乏的大鼠中Zn-Mt-1水平降低可能完全是由于它们的食物摄入量减少（与对照大鼠的15克/天相比为每天8.9克）。
