Department of Dermatology, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland
Department of Pathology, Kuopio University Hospital, 70210 Kuopio, Finland
Eur J Dermatol. 2022 Apr 1;32(2):187-194. doi: 10.1684/ejd.2022.4221.
Patients with cutaneous malignant melanoma (CMM) are at increased risk of non-melanoma skin cancers (NMSCs) and possibly precancerous lesions.
To analyse the association between CMM and not only NMSCs but also precursor lesions, actinic keratosis (AK) and Bowen disease (BD).
MATERIALS & METHODS: The Finnish Cancer Registry data was used to calculate the age-standardized incidence ratio during 2000-2013 for basal (BCC) and squamous (SCC) cell carcinoma in patients with CMM. All tissue material collected from 70,420 subjects during 2000-2013 and reposited in the Biobank of Eastern Finland was used to calculate the age-standardized prevalence of BCC, SCC, BD and AK in CMM patients.
In both genders, the age-standardized incidence ratio of BCC and SCC was increased in CMM patients. The age-standardized prevalence of NMSCs and precursor lesions was higher in patients with CMM than in those without CMM, and was higher in CMM patients with immunosuppression (IS) than in those without IS. The association of M-Snomed subtypes, lentigo maligna (LM), melanoma in situ (MIS) and malignant melanoma (MM) with AK and/or BD was stronger than with BCC. LM revealed the highest association with the combination of AKBD-SCC. Male subjects showed a higher age-standardized prevalence of CMM, MM and BCC than females, but the opposite was observed for AK.
Melanoma increases the risk of NMSCs, and IS may enhance this risk. Both malignant and in situ subtypes of melanoma associate with not only BCC and SCC, but also precancerous lesions.
患有皮肤恶性黑色素瘤（CMM）的患者患非黑色素瘤皮肤癌（NMSC）和可能的癌前病变的风险增加。
分析 CMM 与不仅 NMSC 而且癌前病变、光化性角化病（AK）和 Bowen 病（BD）之间的关联。
使用芬兰癌症登记处的数据，计算 2000-2013 年期间患有 CMM 的患者基底细胞癌（BCC）和鳞状细胞癌（SCC）的年龄标准化发病率比。2000-2013 年期间从 70420 名受试者收集的所有组织材料，并存储在东芬兰生物库中，用于计算 CMM 患者的 BCC、SCC、BD 和 AK 的年龄标准化患病率。
在两性中，CMM 患者的 BCC 和 SCC 的年龄标准化发病率比均增加。与无 CMM 的患者相比，CMM 患者的 NMSC 和癌前病变的年龄标准化患病率更高，且伴有免疫抑制（IS）的 CMM 患者的患病率更高。M-Snomed 亚型、恶性雀斑样痣（LM）、原位黑色素瘤（MIS）和恶性黑色素瘤（MM）与 AK 和/或 BD 的关联强于与 BCC 的关联。LM 与 AKBD-SCC 组合的关联最强。与女性相比，男性患者的 CMM、MM 和 BCC 的年龄标准化患病率较高，但 AK 则相反。
黑色素瘤增加了 NMSC 的风险，IS 可能会增强这种风险。恶性和原位黑色素瘤亚型不仅与 BCC 和 SCC 相关，而且与癌前病变相关。
