Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, Shandong 266071, China.
Department of Neurology, Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.
Chin Med J (Engl). 2022 Jun 20;135(12):1425-1431. doi: 10.1097/CM9.0000000000002228.
Previous studies have shown that inflammation plays an important role in intracranial atherosclerotic stenosis (ICAS). The platelet-to-lymphocyte ratio (PLR) has recently emerged as a potential inflammatory biomarker. This study aimed to explore the association of the PLR with ICAS in a Chinese Han population.
A total of 2134 participants (518 with ICAS, 1616 without ICAS) were enrolled in this study. ICAS was defined as atherosclerotic stenosis >50% or the occlusion of several main intracranial arteries. Multivariable logistic regression analyses were used to assess the association of the PLR with ICAS. Additional subgroup analyses were performed according to age (<60 vs. ≥60 years) and acute ischemic stroke.
Multivariate regression analysis showed that a high PLR was associated with a higher risk of ICAS in all participants ( P < 0.001). Compared with the lowest quartile, the fourth PLR quartile was significantly associated with ICAS (OR 1.705, 95% confidence interval 1.278-2.275, P < 0.001). In the subgroups stratified by age, an association between the PLR and ICAS was found in the late-life group ( P < 0.001), but not in the mid-life group ( P = 0.650). In the subgroups stratified by acute ischemic stroke, the relationship between an elevated PLR and a higher risk of ICAS remained unchanged (stroke group, P < 0.001; non-stroke group, P = 0.027).
An elevated PLR was associated with a higher risk of ICAS in a Chinese Han population. The PLR might serve as a potential biomarker for ICAS in the elderly population.
先前的研究表明，炎症在颅内动脉粥样硬化性狭窄（ICAS）中起着重要作用。血小板与淋巴细胞比值（PLR）最近已成为一种有潜力的炎症生物标志物。本研究旨在探讨汉族人群中 PLR 与 ICAS 的相关性。
本研究共纳入 2134 名参与者（518 名患有 ICAS，1616 名无 ICAS）。ICAS 定义为动脉粥样硬化狭窄>50%或几条主要颅内动脉闭塞。多变量逻辑回归分析用于评估 PLR 与 ICAS 的相关性。根据年龄（<60 岁与≥60 岁）和急性缺血性脑卒中进行了额外的亚组分析。
多变量回归分析表明，高 PLR 与所有参与者的 ICAS 风险增加相关（P<0.001）。与最低四分位数相比，第四 PLR 四分位数与 ICAS 显著相关（OR 1.705，95%置信区间 1.278-2.275，P<0.001）。在按年龄分层的亚组中，PLR 与 ICAS 之间存在关联，尤其是在老年组（P<0.001），但在中年组中无此关联（P=0.650）。在按急性缺血性脑卒中分层的亚组中，高 PLR 与 ICAS 风险增加之间的关系保持不变（脑卒中组，P<0.001；非脑卒中组，P=0.027）。
在汉族人群中，PLR 升高与 ICAS 风险增加相关。PLR 可能是老年人群中 ICAS 的潜在生物标志物。
