Huang Liang-Yu, Sun Fu-Rong, Yin Jian-Jun, Ma Ya-Hui, Li Hong-Qi, Zhong Xiao-Ling, Yu Jin-Tai, Song Jing-Hui, Tan Lan
Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, 266071, China.
Department of Neurology, Qingdao Hiser Hospital, Qingdao University, Qingdao, China.
BMC Neurol. 2021 Feb 5;21(1):56. doi: 10.1186/s12883-021-02073-3.
The neutrophil-to-lymphocyte ratio (NLR) has emerged as an inflammatory marker. However, the associations of NLR with intracranial artery stenosis (ICAS) and ischemic stroke remain unclear. This study aimed to examine the associations of NLR with ICAS and ischemic stroke among a large and high-risk population.
Participants with records of clinical characteristics were prospectively recruited from the Neurology Department and Health & Physical Examination Center of Qingdao Municipal Hospital. Logistic regression analysis was used to examine the associations of NLR with ICAS and ischemic stroke. Moreover, we also conducted parametric mediation analysis to estimate the effect of NLR on the risk of ischemic stroke mediated through ICAS.
A total of 2989 participants were enrolled in this study. After adjusting for covariates, NLR (OR = 1.125, 95%CI 1.070-1.183) and ICAS (OR = 1.638, 95%CI 1.364-1.967) were significantly associated with ischemic stroke. Compared with the first quartile NLR, the second, third and fourth quartiles NLR were independent risk predictors for ischemic stroke (P for trend < 0.001); the third and fourth quartiles were independent predictors for ICAS (P for trend < 0.001). The mediation analysis showed that ICAS partially mediated the association between NLR and ischemic stroke, accounting for 14.4% of the total effect (P < 0.001).
NLR was significantly associated with ICAS and ischemic stroke. Besides, ICAS partially mediated the association between NLR and ischemic stroke.
中性粒细胞与淋巴细胞比值（NLR）已成为一种炎症标志物。然而，NLR与颅内动脉狭窄（ICAS）及缺血性卒中之间的关联仍不明确。本研究旨在探讨在一个大型高危人群中NLR与ICAS及缺血性卒中之间的关联。
前瞻性招募青岛市市立医院神经内科及健康体检中心有临床特征记录的参与者的参与者。采用逻辑回归分析来检验NLR与ICAS及缺血性卒中之间的关联。此外，我们还进行了参数中介分析，以估计NLR通过ICAS对缺血性卒中风险的影响。
本研究共纳入2989名参与者。在调整协变量后，NLR（OR = 1.125，95%CI 1.070 - 1.183）和ICAS（OR = 1.638，95%CI 1.364 - 1.967）与缺血性卒中显著相关。与第一四分位数NLR相比，第二、第三和第四四分位数NLR是缺血性卒中的独立风险预测因子（趋势P < 0.001）；第三和第四四分位数是ICAS的独立预测因子（趋势P < 0.001）。中介分析表明，ICAS部分介导了NLR与缺血性卒中之间的关联，占总效应的14.4%（P < 0.001）。
NLR与ICAS及缺血性卒中显著相关。此外，ICAS部分介导了NLR与缺血性卒中之间的关联。
