Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA.
Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA; Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Neurobiol Aging. 2022 Oct;118:44-54. doi: 10.1016/j.neurobiolaging.2022.06.007. Epub 2022 Jun 25.
We investigated self-rating of cognitive task performance (self-appraisal) and the difference between self-rating and actual task performance (appraisal discrepancy) in cognitively healthy older adults and their relationship with cortical thickness and Alzheimer's disease (AD) biomarkers, amyloid and tau. All participants (N = 151) underwent neuropsychological testing and 1.5T structural magnetic resonance imaging. A subset (N = 66) received amyloid-PET with [11C] PiB and tau-PET with [18F] Flortaucipir. We found that worse performers had lower self-appraisal ratings, but still overestimated their performance, consistent with the Dunning-Kruger effect. Self-appraisal rating and appraisal discrepancy revealed distinct relationships with cortical thickness and AD pathology. Greater appraisal discrepancy, indicating overestimation, was related to thinning of inferior-lateral temporal, fusiform, and rostral anterior cingulate cortices. Lower self-appraisal was associated with higher entorhinal and inferior temporal tau. These results suggest that overestimation could implicate structural atrophy beyond AD pathology, while lower self-appraisal could indicate early behavioral alteration due to AD pathology, supporting the notion of subjective cognitive decline prior to objective deficits.
我们研究了认知任务表现的自我评估（自我评价）以及自我评估与实际任务表现之间的差异（评估差异）在认知健康的老年人及其与皮质厚度和阿尔茨海默病（AD）生物标志物（淀粉样蛋白和 tau）的关系。所有参与者（N=151）均接受神经心理学测试和 1.5T 结构磁共振成像检查。一部分参与者（N=66）接受了[11C]PiB 淀粉样蛋白-PET 和[18F]Flortaucipir tau-PET。我们发现表现较差的人自我评价较低，但仍高估了自己的表现，这与邓宁-克鲁格效应一致。自我评价和评估差异与皮质厚度和 AD 病理显示出不同的关系。较大的评估差异，表明高估，与下外侧颞叶、梭状回和额前扣带回皮质变薄有关。较低的自我评价与更高的内嗅皮质和颞叶 tau 有关。这些结果表明，高估可能暗示除 AD 病理以外的结构萎缩，而自我评价较低可能表明由于 AD 病理导致的早期行为改变，支持在客观缺陷之前存在主观认知下降的观点。
