癌转移中的核仁素 tRF 引发因子
A tRF nucleator for Nucleolin in cancer metastasis.
机构信息
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China; Department of Pharmacy, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310009, China.
Department of Urology, University of California San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA 94158, USA; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94158, USA.
出版信息
Mol Cell. 2022 Jul 21;82(14):2536-2538. doi: 10.1016/j.molcel.2022.06.025.
In this issue of Molecular Cell, Liu et al. (2022) report that 5'-tRF, a stress-induced transfer RNA-derived RNA fragment (tRF) derived from the 5' halves of cysteine tRNAs, regulates post-transcriptional gene expression, enabling the survival and lung metastasis formation of breast cancers.
在本期《分子细胞》中，Liu 等人（2022 年）报道了 5'-tRF，一种应激诱导的转移 RNA 衍生的 RNA 片段（tRF），来源于半胱氨酸转移 RNA 的 5' 端，调节转录后基因表达，使乳腺癌能够存活并发生肺转移。
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