Gao Yang, Shi Huairui, Dong Zhen, Zhang Feng, Sun Aijun, Ge Junbo
Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
Institute of Biomedical Science, Fudan University, Shanghai, China.
J Mol Cell Cardiol. 2022 Oct;171:81-89. doi: 10.1016/j.yjmcc.2022.07.005. Epub 2022 Jul 20.
Pyroptosis is a form of pro-inflammatory, necrotic cell death mediated by proteins of the gasdermin family. Various heart diseases, including myocardial ischemia/reperfusion injury, myocardial infarction, and heart failure, involve cardiomyocyte and non-myocyte pyroptosis. Cardiomyocyte pyroptosis also causes the release of pro-inflammatory cytokines. Recent studies have confirmed that pyroptosis is predominantly triggered by both the canonical and non-canonical inflammasome pathways, which independently facilitate caspase-1 or caspase-11/4/5 activation and gasdermin D (GSDMD) cleavage. Cardiac fibroblast and myeloid cell pyroptosis also contributes to the pathogenesis and development of heart diseases. This review summarizes the recent studies on pyroptosis in heart diseases and discusses the associated therapeutic targets.
细胞焦亡是一种由gasdermin家族蛋白介导的促炎性坏死性细胞死亡形式。包括心肌缺血/再灌注损伤、心肌梗死和心力衰竭在内的各种心脏病都涉及心肌细胞和非心肌细胞的焦亡。心肌细胞焦亡还会导致促炎细胞因子的释放。最近的研究证实，细胞焦亡主要由经典和非经典炎性小体途径触发，这两种途径分别促进半胱天冬酶-1或半胱天冬酶-11/4/5的激活以及gasdermin D（GSDMD）的切割。心脏成纤维细胞和髓样细胞的焦亡也有助于心脏病的发病机制和发展。本综述总结了近期关于心脏病中细胞焦亡的研究，并讨论了相关的治疗靶点。
