School of Graduate Studies, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Department of Cardiology, Tianjin Union Medical Center, Tianjin, China.
Cell Stress Chaperones. 2024 Feb;29(1):158-174. doi: 10.1016/j.cstres.2023.12.003. Epub 2024 Jan 29.
The endoplasmic reticulum (ER) plays a vital function in maintaining cellular homeostasis. Endoplasmic reticulum stress (ERS) can trigger various modes of cell death by activating the unfolded protein response (UPR) signaling pathway. Cell death plays a crucial role in the occurrence and development of diseases such as cancer, liver diseases, neurological diseases, and cardiovascular diseases. Several cardiovascular diseases including hypertension, atherosclerosis, and heart failure are associated with ER stress. ER stress-mediated cell death is of interest in cardiovascular disease. Moreover, an increasing body of evidence supports the potential of modulating ERS for treating cardiovascular disease. This paper provides a comprehensive review of the UPR signaling pathway, the mechanisms that induce cell death, and the modes of cell death in cardiovascular diseases. Additionally, we discuss the mechanisms of ERS and UPR in common cardiovascular diseases, along with potential therapeutic strategies.
内质网（ER）在维持细胞内稳态方面起着至关重要的作用。内质网应激（ERS）可以通过激活未折叠蛋白反应（UPR）信号通路触发多种细胞死亡模式。细胞死亡在癌症、肝脏疾病、神经退行性疾病和心血管疾病等疾病的发生和发展中起着关键作用。几种心血管疾病，包括高血压、动脉粥样硬化和心力衰竭，都与 ER 应激有关。ERS 介导的细胞死亡是心血管疾病研究的热点。此外，越来越多的证据支持调节 ERS 治疗心血管疾病的潜力。本文全面综述了 UPR 信号通路、诱导细胞死亡的机制以及心血管疾病中的细胞死亡模式。此外，我们还讨论了常见心血管疾病中 ERS 和 UPR 的机制以及潜在的治疗策略。
