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钙/钙调蛋白依赖性蛋白激酶 IV 通过小鼠巨噬细胞和角质形成细胞促进咪喹莫特诱导的银屑病炎症。

Calcium/calmodulin-dependent protein kinase IV promotes imiquimod-induced psoriatic inflammation via macrophages and keratinocytes in mice.

机构信息

Department of Dermatology, the First Affiliated Hospital of Anhui Medical University, Hefei, China.

Institute of Dermatology, Anhui Medical University, Hefei, China.

出版信息

Nat Commun. 2022 Jul 22;13(1):4255. doi: 10.1038/s41467-022-31935-8.

DOI:10.1038/s41467-022-31935-8
PMID:35869084
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9307837/
Abstract

CaMK4 has an important function in autoimmune diseases, and the contribution of CaMK4 in psoriasis remains obscure. Here, we show that CaMK4 expression is significantly increased in psoriatic lesional skin from psoriasis patients compared to healthy human skin as well as inflamed skin from an imiquimod (IMQ)-induced mouse model of psoriasis compared to healthy mouse skin. Camk4-deficient (Camk4) mice treated with IMQ exhibit reduced severity of psoriasis compared to wild-type (WT) mice. There are more macrophages and fewer IL-17Aγδ TCR cells in the skin of IMQ-treated Camk4 mice compared to IMQ-treated WT mice. CaMK4 inhibits IL-10 production by macrophages, thus allowing excessive psoriatic inflammation. Deletion of Camk4 in macrophages alleviates IMQ-induced psoriatic inflammation in mice. In keratinocytes, CaMK4 inhibits apoptosis as well as promotes cell proliferation and the expression of pro-inflammatory genes such as S100A8 and CAMP. Taken together, these data indicate that CaMK4 regulates IMQ-induced psoriasis by sustaining inflammation and provides a potential target for psoriasis treatment.

摘要

钙调蛋白依赖性蛋白激酶 4（CaMK4）在自身免疫性疾病中具有重要作用，但其在银屑病中的作用尚不清楚。本研究表明，与健康人皮肤相比，银屑病患者皮损皮肤以及咪喹莫特（IMQ）诱导的银屑病样小鼠模型的炎症皮肤中 CaMK4 的表达显著增加。与野生型（WT）小鼠相比，用 IMQ 处理的 Camk4 缺陷（Camk4）小鼠银屑病的严重程度降低。与 IMQ 处理的 WT 小鼠相比，IMQ 处理的 Camk4 小鼠皮肤中的巨噬细胞增多，而白细胞介素 17AγδT 细胞（IL-17AγδTCR 细胞）减少。CaMK4 抑制巨噬细胞中白细胞介素 10（IL-10）的产生，从而导致过度的银屑病炎症。在巨噬细胞中删除 Camk4 可减轻 IMQ 诱导的小鼠银屑病炎症。在角质形成细胞中，CaMK4 抑制细胞凋亡，促进细胞增殖和促炎基因（如 S100A8 和 CAMP）的表达。总之，这些数据表明 CaMK4 通过维持炎症来调节 IMQ 诱导的银屑病，并为银屑病的治疗提供了一个潜在的靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3496/9307837/1542c1fd99ad/41467_2022_31935_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3496/9307837/68198a5d2c0d/41467_2022_31935_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3496/9307837/75b35cc00a7c/41467_2022_31935_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3496/9307837/65d47bea9bad/41467_2022_31935_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3496/9307837/d863fc9e530b/41467_2022_31935_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3496/9307837/eb064a2b59e6/41467_2022_31935_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3496/9307837/f86472510be5/41467_2022_31935_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3496/9307837/de2a514e9656/41467_2022_31935_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3496/9307837/3793b5d25900/41467_2022_31935_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3496/9307837/ee012b13638a/41467_2022_31935_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3496/9307837/1542c1fd99ad/41467_2022_31935_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3496/9307837/68198a5d2c0d/41467_2022_31935_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3496/9307837/75b35cc00a7c/41467_2022_31935_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3496/9307837/65d47bea9bad/41467_2022_31935_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3496/9307837/d863fc9e530b/41467_2022_31935_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3496/9307837/eb064a2b59e6/41467_2022_31935_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3496/9307837/f86472510be5/41467_2022_31935_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3496/9307837/de2a514e9656/41467_2022_31935_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3496/9307837/3793b5d25900/41467_2022_31935_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3496/9307837/ee012b13638a/41467_2022_31935_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3496/9307837/1542c1fd99ad/41467_2022_31935_Fig10_HTML.jpg

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