Owczarczyk-Saczonek Agnieszka, Czerwińska Joanna, Placek Waldemar
Department of Dermatology, Sexually Transmitted Diseases, and Clinical Immunology, University of Warmia and Mazury, Olsztyn, Poland.
Acta Dermatovenerol Alp Pannonica Adriat. 2018 Mar;27(1):17-23.
Psoriasis is a chronic inflammatory disease with a genetic predisposition that can be triggered by environmental factors. Pathogenesis is characterized by activation of the Th1/Th2 axis and abnormalities of the Th17/Treg balance as well as deficiency of anti-inflammatory cytokines (IL-10, TGF-β). Regulatory lymphocytes (Treg), which are involved in homeostasis mechanisms, maintain tolerance and prevent autoimmune disorders. Only a few studies have investigated the presence of Treg marker expression and levels of anti-inflammatory cytokines in psoriatic skin and sera of patients with psoriasis. The results of studies are controversial. This article reviews and analyzes what is known about the role of Treg cells and anti-inflammatory cytokines in psoriasis.
银屑病是一种具有遗传易感性的慢性炎症性疾病，可由环境因素诱发。其发病机制的特征是Th1/Th2轴激活、Th17/Treg平衡异常以及抗炎细胞因子（IL-10、TGF-β）缺乏。参与稳态机制的调节性淋巴细胞（Treg）维持耐受性并预防自身免疫性疾病。仅有少数研究调查了银屑病患者的银屑病皮肤和血清中Treg标志物表达情况及抗炎细胞因子水平。研究结果存在争议。本文综述并分析了关于Treg细胞和抗炎细胞因子在银屑病中作用的已知情况。
