Department of Vascular and Endovascular Therapy, Augusta Hospital and Catholic Hospital Group, Düsseldorf, Germany.
Germany Faculty of Health, Witten/Herdecke University, Witten, Germany.
Cardiovasc Intervent Radiol. 2022 Sep;45(9):1267-1275. doi: 10.1007/s00270-022-03216-w. Epub 2022 Jul 22.
Sex-based differences in peripheral arterial disease are well-known. Aim of this study was to evaluate sex-related disparities in patients undergoing endovascular treatment of isolated popliteal artery lesions.
Between 1th January 2004 and 1th January 2021 304 patients underwent endovascular treatment of an isolated popliteal artery lesion at three vascular centers. A retrospective analysis was performed comparing the outcomes in female versus male patients.
The majority of the patients were female (51.3%). Male patients were younger (70.4 vs. 76.8 years, p < 0.01). Hyperlipidemia (62.2% vs. 45.5%, p < 0.01) and diabetes (62% vs. 40%, p < 0.01) were more common in male group. There were more current and former smokers in the male group (p = 0.04 and p = 0.01). There were no differences regarding lesion length (mean 94.5 mm) nor location of the lesion. Technical success was comparable in both groups 94.6% vs. 97.4%), no differences in terms of in-hospital complications (9.5% vs. 7.7%) were found. At 3 years estimates did not demonstrate any difference in terms of clinically driven target lesion revascularization (23% vs. 34%), secondary patency (86% vs. 96%), and all-cause mortality (77% vs. 67%) between the two groups.
In our experience the female sex showed clinical signs of popliteal artery lesion at higher age with less aggressive atherosclerotic risk factors. However, during the follow-up no sex-related significant differences were found in terms of morphological and clinical outcomes after endovascular revascularization.
众所周知，外周动脉疾病存在性别差异。本研究旨在评估接受腔内治疗孤立性腘动脉病变的患者中与性别相关的差异。
在 2004 年 1 月 1 日至 2021 年 1 月 1 日期间，有 304 名患者在三个血管中心接受了孤立性腘动脉病变的腔内治疗。对女性与男性患者的结局进行了回顾性分析。
大多数患者为女性（51.3%）。男性患者年龄较小（70.4 岁比 76.8 岁，p<0.01）。男性高脂血症（62.2%比 45.5%，p<0.01）和糖尿病（62%比 40%，p<0.01）更为常见。男性中现吸烟者和既往吸烟者更多（p=0.04 和 p=0.01）。两组患者的病变长度（平均 94.5mm）和病变位置无差异。两组的技术成功率相当（94.6%比 97.4%），住院并发症无差异（9.5%比 7.7%）。3 年时，两组在临床驱动的靶病变血运重建（23%比 34%）、次要通畅率（86%比 96%）和全因死亡率（77%比 67%）方面均无差异。
根据我们的经验，女性发生腘动脉病变的临床征象出现在更高的年龄，且动脉粥样硬化的风险因素较少。然而，在随访中，腔内血管重建后的形态学和临床结局方面，没有发现与性别相关的显著差异。
