.
Department of Gastrology，Mianyang hospital of TCM ，Fucheng Road 14, Mianyang city 621053, Sichuan Province, China.
Cell Mol Biol (Noisy-le-grand). 2022 Feb 28;68(2):189-196. doi: 10.14715/cmb/2022.68.2.27.
This study was carried out to investigate the clinical efficacy of Gegen Qinlian Decoction combined with a Chinese herbal hot package in the treatment of acute gastroenteritis (AGE), and to analyze the effects on serum PCT, CRP and IL-6 levels. For this purpose, 100 patients with AGE admitted to the hospital from January 2019 to January 2022 were selected for the study and randomly divided into observation and control groups, with 50 cases in each group. Patients in the control group were given conventional Western medical treatment, while patients in the observation group were treated with Gegen Qinlian Decoction combined with a Chinese herbal hot package on this basis. The clinical efficacy, symptom relief time, main symptom scores and serum PCT, CRP and IL-6 levels before and after treatment were compared between the two groups. Results showed that the total effective rate of patients in the observation group was significantly higher than that in the control group (P<0.05). After treatment, the disappearance time of diarrhea, abdominal pain, fever and vomiting was significantly shorter in the observation group than in the control group (P<0.05). After treatment, the stool properties, number of stools and abdominal pain symptom scores of patients in both groups were lower than those before treatment, and the symptom scores of patients in the observation group were lower than those in the control group (P<0.05). The PCT, CRP and IL-6 levels of patients in both groups were significantly lower after treatment than before treatment, and the PCT, CRP and IL-6 levels of patients in the observation group were significantly lower than those in the control group (P<0.05). It was concluded that the clinical efficacy of Gegen Qinlian Decoction combined with Chinese herbal hot package in the treatment of AGE is remarkable, which can effectively improve the clinical symptoms and reduce the inflammatory reaction of patients and is worthy of clinical promotion.
本研究旨在探讨葛根芩连汤联合中药热包治疗急性胃肠炎（AGE）的临床疗效，并分析其对血清 PCT、CRP 和 IL-6 水平的影响。为此，选取 2019 年 1 月至 2022 年 1 月我院收治的 100 例 AGE 患者进行研究，并将其随机分为观察组和对照组，各 50 例。对照组患者给予常规西医治疗，观察组患者在此基础上给予葛根芩连汤联合中药热包治疗。比较两组患者的临床疗效、症状缓解时间、主要症状评分及治疗前后血清 PCT、CRP 和 IL-6 水平。结果显示，观察组患者的总有效率明显高于对照组（P<0.05）。治疗后，观察组患者腹泻、腹痛、发热和呕吐消失时间明显短于对照组（P<0.05）。治疗后，两组患者粪便性状、排便次数和腹痛症状评分均低于治疗前，观察组患者症状评分低于对照组（P<0.05）。两组患者治疗后 PCT、CRP 和 IL-6 水平均明显低于治疗前，观察组患者 PCT、CRP 和 IL-6 水平明显低于对照组（P<0.05）。综上所述，葛根芩连汤联合中药热包治疗 AGE 的临床疗效显著，能有效改善患者的临床症状，降低炎症反应，值得临床推广。
