Department of Anatomical Sciences, St George's University, True Blue, Grenada.
Physician Assistant Program, Wagner College, New York, USA.
Clin Anat. 2022 Oct;35(7):1007-1013. doi: 10.1002/ca.23937. Epub 2022 Aug 2.
Investigation into reports of pain treatment for abdominal cancer and abdominal pain syndromes revealed the lack of human studies on some of the abdominal sympathetic ganglia. Recent studies on renal artery denervation therapy as treatment for resistant hypertension has made the aorticorenal ganglia of particular importance. The aim of this study was to investigate the location, morphology, interconnections, and histological nature of aorticorenal ganglia. We dissected nine abdominal cavities and harvested 37 aorticorenal ganglia. Hematoxylin and Eosin, and Masson's staining techniques were used to study the histological structure. Additionally, ganglia harvested from five individuals were stained with immunohistochemical techniques to test for tyrosine hydroxylase activity. All aorticorenal ganglia were located in proximity to the renal artery, and the majority were close to the vessel origin. Identification of multiple aorticorenal ganglia was the norm, and ranged from 2 to 4 on the left and 1 to 3 on the right. While the pattern of aorticorenal ganglia seemed to be unique in each individual case, the interconnections between these and other ganglia were vast. The aorticorenal ganglia shared direct connections with the celiac, gonadal, inferior mesenteric, and first lumbar sympathetic trunk ganglion. Contributions from the greater, lesser, and least thoracic splanchnic nerves were also observed. While the results of our study may not have direct clinical implications in isolation, the vast number of interconnections with the other abdominal ganglia may cause complications in procedures such as celiac ganglion block. In addition, aorticorenal innervation interruption may lead to hypotension.
对腹部癌症疼痛治疗和腹痛综合征报告的调查显示，一些腹部交感神经节缺乏人体研究。最近关于肾动脉去神经治疗作为治疗抵抗性高血压的研究使主动脉肾神经节变得尤为重要。本研究旨在探讨主动脉肾神经节的位置、形态、相互联系和组织学性质。我们解剖了 9 个腹腔，采集了 37 个主动脉肾神经节。使用苏木精和伊红以及 Masson 染色技术研究组织学结构。此外，从 5 个人采集的神经节用免疫组织化学技术染色，以测试酪氨酸羟化酶活性。所有的主动脉肾神经节都位于肾动脉附近，大多数靠近血管起源处。多个主动脉肾神经节的存在是正常的，左侧有 2 到 4 个，右侧有 1 到 3 个。虽然每个个体的主动脉肾神经节模式似乎都是独特的，但这些神经节与其他神经节之间的相互联系非常广泛。主动脉肾神经节与腹腔神经节、性腺神经节、肠系膜下神经节和第 1 腰椎交感神经节有直接联系。还观察到来自较大、较小和最小胸内脏神经的贡献。虽然我们的研究结果孤立地看可能没有直接的临床意义，但与其他腹部神经节的广泛联系可能会导致腹腔神经节阻滞等手术出现并发症。此外，主动脉肾神经支配中断可能导致低血压。
