并非如此“快乐碰撞”：透明质酸引起的并发症。
NOT SO "HAPPY BUMP": A complication due to hyaluronic acid.
机构信息
Sector of Dermatology and Post Graduation Program in Medical Clinics (Area: Dermatology) - University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Cavallieri Clinic, Member of the Brazilian College of Radiology and Diagnostic Imaging and the National Commission of Ultrasound - Brazilian College of Radiology and Diagnostic Imaging, Rio de Janeiro, Brazil.
出版信息
J Cosmet Dermatol. 2022 Nov;21(11):6308-6313. doi: 10.1111/jocd.15266. Epub 2022 Sep 19.
INTRODUCTION
The use of hyaluronic acid (HA) as a dermal filler is considered safe. However, as new brands come to the market, reports of adverse events are becoming more and more common.
OBJECTIVE
To describe a particular type of adverse effect that, unlike the erythematous, indurated, and painful nodules described in the literature as "angry red bumps," is characterized by noninflammatory, stony-like nodules that appear in sites previously treated with HA.
METHODS
The report of four patients who presented this complication, and the occurrence of two HA syringes from the same batch that had hardened the product inside at the time of filling.
CONCLUSION
The authors propose the nomenclature "happy bump" to group adverse reactions to HA that translate into noninflammatory nodules, with a stony consistency, appearing up to 4 weeks (recent) or after one month (late) in sites previously treated with AH.
简介
透明质酸（HA）作为一种真皮填充剂被认为是安全的。然而，随着新品牌进入市场，不良反应的报告越来越常见。
目的
描述一种特殊类型的不良反应，与文献中描述的“红肿硬结”不同，这种不良反应表现为非炎症性、硬结样结节，出现在先前使用 HA 治疗的部位。
方法
报告了 4 名出现这种并发症的患者，以及在填充时同一批的 2 支 HA 注射器出现产品内部变硬的情况。
结论
作者提出了“快乐肿块”这一名词，将 HA 的不良反应归类为非炎症性结节，质地坚硬，出现在先前接受 AH 治疗的部位，时间可长达 4 周（近期）或 1 个月后（晚期）。
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