Division of Cardiac Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Division of Cardiovascular Surgery, University of British Columbia, Vancouver, British Columbia, Canada.
J Card Surg. 2022 Oct;37(10):3050-3056. doi: 10.1111/jocs.16717. Epub 2022 Jul 23.
Acute type A aortic dissection (ATAAD) is a life-threatening condition and surgical repair often includes aortic valve replacement (AVR). Aortic valve repair (AVr) is increasingly being reported with favorable outcomes from single-center experiences. This study examined national trends and outcomes of AVr in patients with ATAAD.
Adults with a primary diagnosis of acute thoracic aortic dissection who underwent proximal aortic surgery from January 2016 to December 2017 were obtained from the National Inpatient Sample. Patients were stratified into an isolated aortic surgery group (no aortic valve procedure), concomitant AVR, or concomitant AVr groups. The primary outcome was in-hospital mortality and secondary outcomes included stroke, acute kidney injury, heart block, and bleeding. Propensity score matching was used to address patient and hospital-level confounders between AVR and AVr groups.
In total, 5115 patients underwent surgery for ATAAD and were included. Overall, 3220 (63%) underwent isolated ATAAD repair, while 1120 (22%) had concomitant AVR, and 775 (15%) had concomitant AVr. In 455 propensity-matched pairs, there was no difference in mortality or stroke between AVr and AVR groups, however, heart block (1.1% vs. 7.5%, p < .001) and bleeding (65.9% vs. 81.3%, p < .001) were significantly less common among those who underwent AVr. Patients who underwent AVr had shortest LOS (11.9 vs. 13.5 days, p < .001). There were no differences in outcomes of AVr in ATAAD based on hospital size or teaching status.
In selected patients, AVr is being performed safely in the setting of ATAAD with mortality and composite outcomes comparable to AVR.
急性 A 型主动脉夹层(ATAAD)是一种危及生命的疾病,手术修复通常包括主动脉瓣置换(AVR)。越来越多的单中心经验报告称,主动脉瓣修复(AVr)的效果良好。本研究调查了 ATAAD 患者中 AVr 的全国趋势和结果。
从 2016 年 1 月至 2017 年 12 月,从国家住院患者样本中获取了接受近端主动脉手术的急性胸主动脉夹层的成人患者。患者分为单纯主动脉手术组(无主动脉瓣手术)、同期 AVR 组或同期 AVr 组。主要结果是住院死亡率,次要结果包括卒、急性肾损伤、心脏传导阻滞和出血。使用倾向评分匹配来解决 AVR 和 AVr 组之间的患者和医院水平混杂因素。
共有 5115 例患者接受 ATAAD 手术,其中 3220 例(63%)接受单纯 ATAAD 修复,1120 例(22%)同期接受 AVR,775 例(15%)同期接受 AVr。在 455 对匹配的患者中,AVr 和 AVR 组在死亡率或卒方面没有差异,但 AVr 组心脏传导阻滞(1.1%比 7.5%,p<0.001)和出血(65.9%比 81.3%,p<0.001)明显较少。接受 AVr 的患者 LOS 最短(11.9 比 13.5 天,p<0.001)。根据医院规模或教学地位,AVr 在 ATAAD 中的结果没有差异。
在选择的患者中,AVr 在 ATAAD 中安全进行,死亡率和复合结果与 AVR 相当。